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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Agronomy and Animal Industries</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Agronomy and Animal Industries</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Агрономия и животноводство</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2312-797X</issn><issn publication-format="electronic">2312-7988</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">19872</article-id><article-id pub-id-type="doi">10.22363/2312-797X-2023-18-1-135-144</article-id><article-id pub-id-type="edn">ZDSVNC</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Veterinary science</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Ветеринария</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Treatment for cholangiohepatitis in cats</article-title><trans-title-group xml:lang="ru"><trans-title>Лечение кошек при холангиогепатите</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6434-3497</contrib-id><name-alternatives><name xml:lang="en"><surname>Rudenko</surname><given-names>Andrei A.</given-names></name><name xml:lang="ru"><surname>Руденко</surname><given-names>Андрей Анатольевич</given-names></name></name-alternatives><bio xml:lang="en"><p>Doctor of Veterinary Sciences, Professor, Department of Veterinary Medicine, Moscow State University of Food Production; Associate Professor, Department of Veterinary Medicine, Agrarian and Technological Institute, Peoples’ Friendship University of Russia (RUDN University)</p></bio><bio xml:lang="ru"><p>доктор ветеринарных наук, профессор, кафедра ветеринарной медицины, Московский государственный университет пищевых производств; доцент департамента ветеринарной медицины аграрно-технологического института, Российский университет дружбы народов</p></bio><email>vetrudek@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Karamyan</surname><given-names>Arfenia S.</given-names></name><name xml:lang="ru"><surname>Карамян</surname><given-names>Арфения Семеновна</given-names></name></name-alternatives><bio xml:lang="en">Candidate of Biological Sciences, Associate Professor, Department of Veterinary Medicine, Agrarian and Technological Institute</bio><bio xml:lang="ru">кандидат биологических наук, доцент, департамент ветеринарной медицины, аграрно-технологический институт</bio><email>karamyan-as@rudn.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3757-9998</contrib-id><name-alternatives><name xml:lang="en"><surname>Usenko</surname><given-names>Denis S.</given-names></name><name xml:lang="ru"><surname>Усенко</surname><given-names>Денис Сергеевич</given-names></name></name-alternatives><bio xml:lang="en"><p>Post-graduate student, Department of Infectious Diseases and Forensic Veterinary Medicine</p></bio><bio xml:lang="ru"><p>аспирант кафедры инфекционных болезней и судебной ветеринарной медицины</p></bio><email>den-usenko@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1771-6091</contrib-id><name-alternatives><name xml:lang="en"><surname>Krotova</surname><given-names>Elena A.</given-names></name><name xml:lang="ru"><surname>Кротова</surname><given-names>Елена Александровна</given-names></name></name-alternatives><bio xml:lang="en"><p>Candidate of Biological Sciences, Associate Professor, Department of Veterinary Medicine, Agrarian and Technological Institute</p></bio><bio xml:lang="ru"><p>кандидат биологических наук, доцент, департамент ветеринарной медицины, аграрно-технологический институт</p></bio><email>krotova-ea@rudn.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3010-5714</contrib-id><name-alternatives><name xml:lang="en"><surname>Rogov</surname><given-names>Roman V.</given-names></name><name xml:lang="ru"><surname>Рогов</surname><given-names>Роман Васильевич</given-names></name></name-alternatives><bio xml:lang="en"><p>Candidate of Biological Sciences, Associate Professor, Department of Veterinary Medicine, Agrarian and Technological Institute</p></bio><bio xml:lang="ru"><p>кандидат биологических наук, доцент, департамент ветеринарной медицины, аграрно-технологический институт</p></bio><email>rogov-rv@rudn.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1849-3849</contrib-id><name-alternatives><name xml:lang="en"><surname>Prozorovskiy</surname><given-names>Ivan E.</given-names></name><name xml:lang="ru"><surname>Прозоровский</surname><given-names>Иван Ежиевич</given-names></name></name-alternatives><bio xml:lang="en"><p>Associate Professor, Department of Veterinary Medicine, Agrarian and Technological Institute</p></bio><bio xml:lang="ru"><p>доцент, департамент ветеринарной медицины, аграрно-технологический институт</p></bio><email>prozorovskiy-ie@rudn.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Peoples’ Friendship University of Russia (RUDN University)</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Moscow State University of Food Production</institution></aff><aff><institution xml:lang="ru">Московский государственный университет пищевых производств</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Lugansk State Agrarian University</institution></aff><aff><institution xml:lang="ru">Луганский государственный аграрный университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-03-30" publication-format="electronic"><day>30</day><month>03</month><year>2023</year></pub-date><volume>18</volume><issue>1</issue><issue-title xml:lang="en">VOL 18, NO1 (2023)</issue-title><issue-title xml:lang="ru">ТОМ 18, №1 (2023)</issue-title><fpage>135</fpage><lpage>144</lpage><history><date date-type="received" iso-8601-date="2023-04-06"><day>06</day><month>04</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Rudenko A.A., Karamyan A.S., Usenko D.S., Krotova E.A., Rogov R.V., Prozorovskiy I.E.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Руденко А.А., Карамян А.С., Усенко Д.С., Кротова Е.А., Рогов Р.В., Прозоровский И.Е.</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Rudenko A.A., Karamyan A.S., Usenko D.S., Krotova E.A., Rogov R.V., Prozorovskiy I.E.</copyright-holder><copyright-holder xml:lang="ru">Руденко А.А., Карамян А.С., Усенко Д.С., Кротова Е.А., Рогов Р.В., Прозоровский И.Е.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://agrojournal.rudn.ru/agronomy/article/view/19872">https://agrojournal.rudn.ru/agronomy/article/view/19872</self-uri><abstract xml:lang="en"><p style="text-align: justify;">Acute bacterial cholangiohepatitis of cats is a common disease associated with the inflammation of bile ducts and liver parenchyma, characterized by development of a pronounced hepatodepressive syndrome (hypoalbuminemia), cytolysis (increase in serum activity of alanine and asparagine transaminase), cholestasis (increase in serum concentration of bilirubin, cholesterol, activity of alkaline phosphatase and gamma-glutamyltranspeptidase), intoxication, dehydration, mesenchymal-inflammatory and pain syndromes. The aim of the research was to study the effectiveness of treatment for acute bacterial cholangiohepatitis in cats with average severity of the pathology course. According to inclusion and exclusion criteria, the study included a cohort of cats (n = 12) with acute bacterial cholangiohepatitis. Clinical, hematological, ultrasonographic, statistical methods of investigation were used in this work. For sick cats with medium severity form of cholangiohepatitis, when administered as a complex therapy the combination of marbofloxacin, metronidazole, ursodeoxycholic acid, cyancobolamine, tocopherol acetate, infusion therapy also had a good therapeutic effect, which was accompanied by improved clinical and laboratory performance. In the blood of cats with cholangiohepatitis, in the background of intensive therapy, there was a significant decrease in white blood cell count, erythrocyte sedimentation rate, and in serum, there was an increase in albumin concentration, reduction of creatinine, aminotransferase activity, alkaline phosphatase, gamma-glutamyltranspeptidase, lipase.</p></abstract><trans-abstract xml:lang="ru"><p style="text-align: justify;">Острый бактериальный холангиогепатит кошек представляет собой чрезвычайно распространенную патологию, связанную с воспалением паренхимы печени и желчных протоков, характеризующуюся развитием гепатодепрессивного синдрома (гипоальбуминемии), цитолиза (повышение активности аспарагиновой и аланиновой трансаминазы в сыворотке крови), холестаза (повышение сывороточной концентрации билирубина, холестерина, активности гамма-глутамилтранспептидазы и щелочной фосфатазы), интоксикации, дегидратации, мезенхимально-воспалительного и болевого синдромов. Цель исследования - изучить эффективность лечения кошек с острым бактериальным холангиогепатитом при средней степени тяжести течения патологии. Согласно критериям включения и исключения в исследование проводили на группе кошек (n = 12) с острым бактериальным холангиогепатитом. Использовали клинические, гематологические, ультразвуковые, статистические методы исследования. У больных кошек при средней форме холангиогепатита при назначении в составе комплексной терапии комбинация метронидазола, марбофлоксацина, урсодезоксихолевой кислоты, токоферола ацетата, цианкоболамина при инфузионном введении оказывала хороший терапевтический эффект, что сопровождалось улучшением клинико-лабораторных показателей. В крови кошек с холангиогепатитом на фоне интенсивной терапии наблюдалось достоверное снижение количества лейкоцитов, скорости оседания эритроцитов, а в сыворотке крови - повышение концентрации альбумина, снижение активности аминотрансферазы, гамма-глутамилтранспептидазы, щелочной фосфатазы, липазы, концентрации креатинина.</p></trans-abstract><kwd-group xml:lang="en"><kwd>cholangitis</kwd><kwd>hepatitis</kwd><kwd>effectiveness of treatment</kwd><kwd>analgesia</kwd><kwd>marbofloxacin</kwd><kwd>metrogyl</kwd><kwd>urodeoxycholic acid</kwd><kwd>lidocaine</kwd><kwd>maropitant</kwd><kwd>gabapentin</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>холангит</kwd><kwd>гепатит</kwd><kwd>эффективность лечения</kwd><kwd>анальгезия</kwd><kwd>марбофлоксацин</kwd><kwd>метрогил</kwd><kwd>уродезоксихолевая кислота</kwd><kwd>лидокаин</kwd><kwd>маропитант</kwd><kwd>габапентин</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Vatnikov Y, Vilkovysky I, Kulikov E, Popova I, Khairova N, Gazin A, Zharov A, Lukina D. 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