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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Agronomy and Animal Industries</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Agronomy and Animal Industries</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Агрономия и животноводство</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2312-797X</issn><issn publication-format="electronic">2312-7988</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">19906</article-id><article-id pub-id-type="doi">10.22363/2312-797X-2023-18-2-250-263</article-id><article-id pub-id-type="edn">SLOZKK</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Veterinary science</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Ветеринария</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Effectiveness of Farnesol for treatment of dog otitis complicated by Malassezia pachydermatis</article-title><trans-title-group xml:lang="ru"><trans-title>Эффективность применения Фарнезола для лечения отитов собак, осложненных Malassezia pachydermatis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2395-7350</contrib-id><name-alternatives><name xml:lang="en"><surname>Olabode</surname><given-names>Ifarajimi R.</given-names></name><name xml:lang="ru"><surname>Олабодэ</surname><given-names>Ифараджими Рафиль</given-names></name></name-alternatives><bio xml:lang="en"><p>postgraduate student, Department of Veterinary Medicine, Agrarian and Technological Institute</p></bio><bio xml:lang="ru"><p>аспирант департамента ветеринарной медицины аграрно-технологического института</p></bio><email>1042205126@rudn.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1100-929X</contrib-id><contrib-id contrib-id-type="spin">1172-3163</contrib-id><name-alternatives><name xml:lang="en"><surname>Sachivkina</surname><given-names>Nadezhda P.</given-names></name><name xml:lang="ru"><surname>Сачивкина</surname><given-names>Надежда Павловна</given-names></name></name-alternatives><bio xml:lang="en"><p>Candidate of Biological Sciences, Associate Professor, Department of Microbiology, Medical Institute</p></bio><bio xml:lang="ru"><p>кандидат биологических наук, доцент, доцент кафедры микробиологии им. В.С. Киктенко медицинского института</p></bio><email>sachivkina@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4907-9384</contrib-id><name-alternatives><name xml:lang="en"><surname>Kiseleva</surname><given-names>Ekaterina V.</given-names></name><name xml:lang="ru"><surname>Киселева</surname><given-names>Екатерина Васильевна</given-names></name></name-alternatives><bio xml:lang="en"><p>veterinarian, Nikulin Circus on Tsvetnoy Boulevard ; postgraduate student, Department of Zoology and Animal Ecology, Pskov State University</p></bio><bio xml:lang="ru"><p>ветеринарный врач, Цирк Никулина на Цветном бульваре; аспирант кафедры зоологии и экологии животных, Псковский государственный университет</p></bio><email>kirsanovakaterina@yandex.ru</email><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2289-9814</contrib-id><contrib-id contrib-id-type="spin">9286-9577</contrib-id><name-alternatives><name xml:lang="en"><surname>Shurov</surname><given-names>Aleksey I.</given-names></name><name xml:lang="ru"><surname>Щуров</surname><given-names>Алексей Игоревич</given-names></name></name-alternatives><bio xml:lang="en"><p>postgraduate student, Department of Veterinary Medicine, veterinarian, Center for Veterinary Innovative Medicine, Agrarian and Technological Institute</p></bio><bio xml:lang="ru"><p>аспирант департамента ветеринарной медицины, врач центра ветеринарной инновационной медицины, аграрно-технологический институт</p></bio><email>shurov_ai@rudn.university</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">RUDN University</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Pskov State University</institution></aff><aff><institution xml:lang="ru">Псковский государственный университет</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Nikulin Circus on Tsvetnoy Boulevard</institution></aff><aff><institution xml:lang="ru">Цирк Никулина на Цветном бульваре</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-06-30" publication-format="electronic"><day>30</day><month>06</month><year>2023</year></pub-date><volume>18</volume><issue>2</issue><issue-title xml:lang="en">VOL 18, NO2 (2023)</issue-title><issue-title xml:lang="ru">ТОМ 18, №2 (2023)</issue-title><fpage>250</fpage><lpage>263</lpage><history><date date-type="received" iso-8601-date="2023-07-09"><day>09</day><month>07</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Olabode I.R., Sachivkina N.P., Kiseleva E.V., Shurov A.I.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Олабодэ И.Р., Сачивкина Н.П., Киселева Е.В., Щуров А.И.</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Olabode I.R., Sachivkina N.P., Kiseleva E.V., Shurov A.I.</copyright-holder><copyright-holder xml:lang="ru">Олабодэ И.Р., Сачивкина Н.П., Киселева Е.В., Щуров А.И.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://agrojournal.rudn.ru/agronomy/article/view/19906">https://agrojournal.rudn.ru/agronomy/article/view/19906</self-uri><abstract xml:lang="en"><p style="text-align: justify;">The study involved 30 dogs with otitis complicated by Malassezia pachydermatis . The animals were divided into 2 groups: experimental (n = 15) and control (n = 15). The experimental group was prescribed veterinary ear drops Surolan + a solution of the drug Farnesol; the control group - Surolan. The study showed that when Farnesol is added to the treatment regimen for fungal otitis etiology in dogs, small changes in the clinical composition of the blood are recorded, characterized by an increase in the number of erythrocytes and hemoglobin, a decrease in the number of leukocytes, with a decrease in the indicators of eosinophils and rod-shaped neutrophils in the experiment compared with the control. In addition, the complete absence of Malassezia pachydermatis in the smears of the ear contents after two weeks of therapy with a combined drug was proved. That is, in the experimental group, there were no cases of the presence of yeast-like fungi (YLF) in the smear after combined therapy with Surolan + Farnesol. And in the control group of 15 animals, YLF were observed in two with microscopy of ear exudate smears, but not in high concentration. The use of a combination of Surolan and Farnesol in dogs of the experimental group led to a decrease in hyperemia, itching, edema, ear fetid fluid on the 5th…7th days of treatment, and complete clinical recovery of the animals occurred by the 10th…14th day of therapy. In the control group, only Surolan was used, and improvement of clinical condition occurred on days 12…14, and recovery only after completion of the full course. As a result, both treatment regimens were successful, but the scheme with Farnesol gave faster results due to the wide spectrum of action of this drug: both antimicrobial and anti-inflammatory.</p></abstract><trans-abstract xml:lang="ru"><p style="text-align: justify;">В исследовании было задействовано 30 собак с отитом, осложненным Malassezia pachydermatis . Животных разделили на 2 группы: опытную (n = 15) и контрольную (n = 15). Опытной группе были назначены капли ушные ветеринарные Суролан + раствор препарата Фарнезол; контрольной - Суролан. В ходе исследования показано, что при добавлении Фарнезола в схему лечения отитов грибковой этиологии у собак регистрируются небольшие изменения клинического состава крови, характеризующиеся увеличением количества эритроцитов и гемоглобина, снижением числа лейкоцитов; в то же время снижаются показатели эозинофилов и палочкоядерных нейтрофилов в опыте по сравнению с контролем. Кроме того, доказано полное отсутствие Malassezia pachydermatis в мазках ушного содержимого после двухнедельной терапии сочетанным препаратом. Т.е. в опытной группе не было зарегистрировано ни одного случая присутствия дрожжеподобных грибов (ДПГ) в мазке после сочетанной терапии Суролан + Фарнезол, а в контрольной группе из 15 животных у двух при микроскопии мазков ушного экссудата ДПГ наблюдались, но не в большой концентрации. Использование комбинации Суролана и Фарнезола у собак опытной группы привело к уменьшению гиперемии, зуда, отека, ушной зловонной жидкости на 5…7 дни лечения, а полное клиническое выздоровление животных наступало к 10…14 дню терапии. В контрольной группе использовался только Суролан и улучшение клинического состояния наступало на 12…14 дни, а выздоровление - только по завершении полного курса. В итоге обе схемы лечения оказались успешными, однако схема с Фарнезолом дала более быстрые результаты, обусловленные широким спектром действия этого препарата: антимикробным и противовоспалительным.</p></trans-abstract><kwd-group xml:lang="en"><kwd>yeast-like fungi</kwd><kwd>mycosis</kwd><kwd>clinical blood test</kwd><kwd>phytotherapy</kwd><kwd>Surolan</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>дрожжеподобные грибы</kwd><kwd>микозы</kwd><kwd>клинический анализ крови</kwd><kwd>фитотерапия</kwd><kwd>Суролан</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Dutova OG, Kraskova EV, Radyuk I.E. The comparison of otitis etiology and treatment in small nonproducing animals. Bulletin of Altai State Agricultural University. 2016;(9):125–128. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Дутова О.Г., Краскова Е.В., Радюк И.Е. 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