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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Agronomy and Animal Industries</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Agronomy and Animal Industries</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Агрономия и животноводство</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2312-797X</issn><issn publication-format="electronic">2312-7988</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">19960</article-id><article-id pub-id-type="doi">10.22363/2312-797X-2023-18-4-591-603</article-id><article-id pub-id-type="edn">NQMYPE</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Veterinary science</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Ветеринария</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Surgical treatment of colorectal tubular adenoma in dog</article-title><trans-title-group xml:lang="ru"><trans-title>Оперативное лечение тубулярной аденомы прямой кишки у собаки</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4726-6204</contrib-id><contrib-id contrib-id-type="spin">8388-6880</contrib-id><name-alternatives><name xml:lang="en"><surname>Nazarova</surname><given-names>Anna V.</given-names></name><name xml:lang="ru"><surname>Назарова</surname><given-names>Анна Вениаминовна</given-names></name></name-alternatives><bio xml:lang="en"><p>Candidate of Veterinary Sciences, Assistant, Department of General, Private and Operative Surgery</p></bio><bio xml:lang="ru"><p>кандидат ветеринарных наук, ассистент кафедры общей, частной и оперативной хирургии</p></bio><email>anna.v.nazarova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0149-9360</contrib-id><contrib-id contrib-id-type="spin">3640-3949</contrib-id><name-alternatives><name xml:lang="en"><surname>Semenov</surname><given-names>Boris S.</given-names></name><name xml:lang="ru"><surname>Семенов</surname><given-names>Борис Степанович</given-names></name></name-alternatives><bio xml:lang="en"><p>Doctor of Veterinary Sciences, Professor, Department of General, Private and Operative Surgery</p></bio><bio xml:lang="ru"><p>доктор ветеринарных наук, профессор кафедры общей, частной и оперативной хирургии</p></bio><email>bsstepana@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8981-0696</contrib-id><contrib-id contrib-id-type="spin">1240-5278</contrib-id><name-alternatives><name xml:lang="en"><surname>Kuznetsova</surname><given-names>Tatyana S.</given-names></name><name xml:lang="ru"><surname>Кузнецова</surname><given-names>Татьяна Шамильевна</given-names></name></name-alternatives><bio xml:lang="en"><p>Candidate of Biological Sciences, Associate Professor, Department of Genetic and Reproductive Biotechnologies</p></bio><bio xml:lang="ru"><p>кандидат биологических наук, доцент кафедры генетических и репродуктивных биотехнологий</p></bio><email>kuznett@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Saint Petersburg State University of Veterinary Medicine</institution></aff><aff><institution xml:lang="ru">Санкт-Петербургский государственный университет ветеринарной медицины</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2023</year></pub-date><volume>18</volume><issue>4</issue><issue-title xml:lang="en">Pesticides. Looking to the future</issue-title><issue-title xml:lang="ru">Пестициды. Взгляд в будущее</issue-title><fpage>591</fpage><lpage>603</lpage><history><date date-type="received" iso-8601-date="2023-12-29"><day>29</day><month>12</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Nazarova A.V., Semenov B.S., Kuznetsova T.S.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Назарова А.В., Семенов Б.С., Кузнецова Т.Ш.</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Nazarova A.V., Semenov B.S., Kuznetsova T.S.</copyright-holder><copyright-holder xml:lang="ru">Назарова А.В., Семенов Б.С., Кузнецова Т.Ш.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://agrojournal.rudn.ru/agronomy/article/view/19960">https://agrojournal.rudn.ru/agronomy/article/view/19960</self-uri><abstract xml:lang="en"><p style="text-align: justify;">The surgical methods for treatment of adenomatous polyps in dogs and their effectiveness for maintaining health and quality of life of the animal were studied. The study was conducted on the clinical case of colorectal tubular adenoma (TA) surgical treatment in a 11-year-old male Irish setter who was admitted for hematochezia. A colonoscopy revealed a colon wall neoplasm. Based on the data of cytological and histological examination of the biopsy material, the patient was diagnosed with «tubular adenoma of the rectum». Computed tomography revealed a mass 57×18.3×18.3 mm in the rectal ampoule. After tissue segmentation, to make a therapeutic decision about the possibility of surgical resection and access, the ampoule of the rectum was resected through dorsal access. In the early postoperative period, tenesmus (with a decrease in their severity within a week after surgery) and partial fecal incontinence were recorded. The most serious complication was the formation of several more defects of the colon wall cranially from the superimposed anastomoses, which required three more operations. To decompress the colorectal anastomosis, a temporary flank double-barrelled colostomy with a support bridge was performed. The study revealed that despite the relatively rare incidence of TA in dogs, the comparison investigation of diagnosis and surgical treatment methods and avoiding postoperative complications and tumor recurrence is a relevant task both due to the possibility of TA malignancy and due to the fact that dogs are a naturally biological model for investigating this pathology.</p></abstract><trans-abstract xml:lang="ru"><p style="text-align: justify;">Отражены результаты изучения возможных оперативных приемов при лечении аденоматозных полипов у собак и их эффективность для поддержания здоровья и качества жизни животного. Исследование проведено на основе клинического случая хирургического лечения тубулярной аденомы (ТА) ампулы прямой кишки у одиннадцатилетнего кобеля ирландского сеттера, поступившего на прием по поводу гематохезии. При проведении колоноскопии было выявлено новообразование на стенке кишечника. На основании данных цитологического и гистологического исследований биопсийного материала пациенту был поставлен диагноз «тубулярная аденома прямой кишки». По результатам проведенной пациенту компьютерной томографии выявлено объемное образование в анатомическом расположении ампулы прямой кишки, его размеры 57×18,3×18,3 мм. На основании данных сегментацией тканей собаке была спланирована и выполнена полностенная резекция ампулы прямой кишки через дорсальный доступ. В ранний послеоперационный период были зарегистрированы тенезмы (с уменьшением их выраженности в течение недели после операции) и частичное недержание кала. Самым серьезным осложнением стало множественное формирование новых дефектов кишки краниальнее накладываемых анастомозов, что потребовало проведения еще трех операций. Для декомпрессии колоректального анастомоза собаке была выведена временная двуствольная колостома с опорой на стержень. Проведенное исследование показало, что несмотря на относительно редкую инцидентность ТА у собак, изучение и сравнение современных методов ее диагностики, хирургического лечения и профилактики послеоперационных осложнений и рецидивов опухоли - актуальная задача как вследствие возможности малигнизации ТА, так и того, что собаки являются естественной биологической моделью для изучения этой патологии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>inflammatory colorectal polyps</kwd><kwd>colorectal cancer</kwd><kwd>colostomy</kwd><kwd>аdenomatous polyps of the colon</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>воспалительный колоректальный полип</kwd><kwd>аденоматозный полип</kwd><kwd>колоректальный рак</kwd><kwd>колостома</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Mcentee MF, Cates JM, Neilsen N. Cyclooxygenase-2 expression in spontaneous intestinal neoplasia of domestic dogs. Veterinary pathology. 2002;39(4):428-436. doi: 10.1354/vp.39-4-428</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Yoshizaki K, Hirata A, Matsushita H, Sakaguchi M, Yoneji W, Owaki K, et al. Molecular epidemiological study of germline APC variant associated with hereditary gastrointestinal polyposis in dogs: current frequency in Jack Russell Terriers in Japan and breed distribution. BMC Veterinary Research. 2022;18(1):230. doi: 10.1186/s12917-022-03338-w</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Igarashi H, Ohno K, Matsuki N, Fujiwara-I garashi A, Kanemoto H, Fukushima K, et al. Analysis of fecal short chain fatty acid concentration in miniature dachshunds with inflammatory colorectal polyps. Journal of Veterinary Medical Science. 2017;79(10):1727-1734. doi: 10.1292/jvms.17-0165</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Yoshizaki K, Hirata A, Matsushita H, Sakaguchi M, Yoneji W, Owaki K, Sakai H. Molecular epidemiological study of germline APC variant associated with hereditary gastrointestinal polyposis in dogs: current frequency in Jack Russell Terriers in Japan and breed distribution. BMC Veterinary Research. 2022;18(1):230. doi: 10.1186/s12917-022-03338-w</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Ohmi A, Ohno K, Chambers JK, Uchida K, Nakagawa T, Tomiyasu H, Tsujimoto H. Clinical and histopathological features and prognosis of gastrointestinal adenocarcinomas in Jack Russell Terriers. Journal of Veterinary Medical Science. 2021;83(2):167-173. doi: 10.1292/jvms.20-0421</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Yoneji W, Yoshizaki K, Hirata A, Yoneji K, Sakai H. Clinical and pathological diagnosis of hereditary gastrointestinal polyposis in Jack Russell Terriers. Veterinary Sciences. 2022;9(10):551. doi: 10.3390/vetsci9100551</mixed-citation></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">Muzaffarova ТА, Karpukhin AV. Features of mutations in АРС gene. Universum: Medicine and Pharmacology. 2016;(11). Available from: http://7universum.com/ru/med/archive/item/3859 (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Музаффарова Т.А., Карпухин А.В. Особенности мутаций в гене АРС // Universum: Медицина и фармакология: электрон. научн. журн. 2016. № 11(33). Режим доступа: http://7universum.com/ru/med/archive/item/3859 Дата обращения: 12.08.2023.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">Gamisonia AM. Gene АРС. GENOCARD Genetic Encyclopedia. 2019. Available from: https://www.genokarta.ru/gene/APC (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Гамисония А.М. Ген APC // ГЕНОКАРТА Генетическая энциклопедия. 2019. Режим доступа: https://www.genokarta.ru/gene/APC Дата обращения: 12.08.2023.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><mixed-citation>Zhang Y, Pu W, Bousquenaud M, Cattin S, Zaric J, Sun LK, et al. Emodin inhibits inflammation, carcinogenesis, and cancer progression in the AOM/DSS Model of Colitis-A ssociated Intestinal Tumorigenesis. Front Oncol. 2021;10:564674. doi: 10.3389/fonc.2020.564674</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Herstad KMV, Moen AEF, Gaby JC, Moe L, Skancke E. Characterization of the fecal and mucosa-associated microbiota in dogs with colorectal epithelial tumors. PLoS One. 2018;13(5): e0198342. doi: 10.1371/journal.pone.0198342</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Oliveira AR, Flecher MC, Horta RS, Souza MCC, Hardt I, Gonçalves ABB, et al. Tubulopapillary rectal adenocarcinoma in dog: clinical, surgical, pathological and immunophenotypical aspects: case report. Arquivo Brasileiro de Medicina Veterinária e Zootecnia. 2018;70:463-468. doi: 10.1590/1678-4162-9459</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Noshirwani KC, Van Stolk RU, Rybicki LA, Beck GJ. Adenoma size and number are predictive of adenoma recurrence: implications for surveillance colonoscopy. Gastrointestinal Endoscopy. 2000;51(4-1):433-437. doi: 10.1016/S0016-5107(00)70444-5</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Willard MD. Alimentary neoplasia in geriatric dogs and cats. Veterinary Clinics: Small Animal Practice. 2012;42(4):693-706. doi: 10.1016/j.cvsm.2012.04.006</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Richardson MA, Thaiwong T, Kiupel M. Primary colorectal follicular lymphoma in 3 dogs. Vet Pathol. 2019;56(3):404-408. doi: 10.1177/0300985818823775</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Seiler RJ. Colorectal polyps of the dog: a clinicopathologic study of 17 cases. J Am Vet Med Assoc. 1979;174(1):72-75.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Levine JS, Ahnen DJ. Adenomatous polyps of the colon. New England Journal of Medicine. 2006;355(24):2551-2557. doi: 10.1056/NEJMcp063038</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Adamovich-R ippe KN, Mayhew PD, Marks SL, Selmic LE, Culp WT, Youello AM, et al. Colonoscopic and histologic features of rectal masses in dogs: 82 cases (1995-2012). J Am Vet Med Assoc. 2017;250(4):424-430. doi: 10.2460/javma.250.4.424</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Wolff E, Van Vertloo L, Salisbury SK, Childress MO. Obturator-assisted prolapse for access to and sampling of colorectal masses in seven dogs. J Am Anim Hosp Assoc. 2020;56(3): e563-02. doi: 10.5326/JAAHA-MS-6961</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Cantatore M, Jimeno Sandoval JC, Das S, Sesana A, Charlesworth T, Ryan T, et al. Submucosal resection via a transanal approach for treatment of epithelial rectal tumors - a multicenter study. Vet Surg. 2022;51(3):397-408. doi: 10.1111/vsu.13766</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Dumont F, Mariani A, Elias D, Goéré D. Surgical strategy for low rectal cancers. J Visc Surg. 2015;152(1):23-31. doi: 10.1016/j.jviscsurg.2014.10.005</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Danova NA, Robles-E manuelli JC, Bjorling DE. Surgical excision of primary canine rectal tumors by an anal approach in twenty-three dogs. Vet Surg. 2006;35(4):337-340. doi: 10.1111/j.1532-950X.2006.00154.x</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Morello E, Martano M, Squassino C, Iussich S, Caccamo R, Sammartano F, et al. Transanal pull-through rectal amputation for treatment of colorectal carcinoma in 11 dogs. Vet Surg. 2008;37(5):420-426. doi: 10.1111/j.1532-950X.2008.00404.x</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Nucci DJ, Liptak JM, Selmic LE, Culp WT, Durant AM, Worley D, et al. Complications and outcomes following rectal pull-through surgery in dogs with rectal masses: 74 cases (2000-2013). J Am Vet Med Assoc. 2014;245(6):684-695. doi: 10.2460/javma.245.6.684</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Güenaga KF, Lustosa SA, Saad SS, Saconato H, Matos D. Ileostomy or colostomy for temporary decompression of colorectal anastomosis. Cochrane Database Syst Rev. 2007; (1): CD004647. doi: 10.1002/14651858.CD004647.pub2</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Cinti F, Pisani G. Temporary end-on colostomy as a treatment for anastomotic dehiscence after a transanal rectal pull-through procedure in a dog. Vet Surg. 2019;48(5):897-901. doi: 10.1111/vsu.13152</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Falerno I, Collivignarelli F, Vignoli M, Paolini A, Tamburro R. The use of a vascularized pedicle jejunal graft as a treatment for anastomosis dehiscence after transanal pull-through, with a combined approach, in two dogs. Clin Case Rep. 2021;9(8): e04182. doi: 10.1002/ccr3.4182</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Kumagai D, Shimada T, Yamate J, Ohashi F. Use of an incontinent end-on colostomy in a dog with annular rectal adenocarcinoma. J Small Anim Pract. 2003;44(8):363-366. doi: 10.1111/j.1748-5827.2003.tb00169.x</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Hardie EM, Gilson SD. Use of colostomy to manage rectal disease in dogs. Vet Surg. 1997;26(4):270-274. doi: 10.1111/j.1532-950x.1997.tb01498.x</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Bloemendaal ALA, Kraus R, Buchs NC, Hamdy FC, Hompes R, Cogswell L, et al. Double-barrelled wet colostomy formation after pelvic exenteration for locally advanced or recurrent rectal cancer. 2016;18(11): O427-O431 doi: 10.1111/codi.13512https://onlinelibrary.wiley.com/doi/full/10.1111/codi.13512</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Han J, Wang Z, Wei G, Zhai Z, Ma L, Yi B, et al. Application of modified purse-string closure in the wound following loop stoma reversal. Chinese Journal of Gastrointestinal Surgery. 2018;21(12):1403-1407. (In Chinese).</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Samy A, Abdalla A, Rizk A. Evaluation of short-term loop colostomy in dogs using conventional and supporting subcutaneous silicone drain techniques. J Adv Vet Anim Res. 2020;7(4):685-691. doi: 10.5455/javar.2020.g468</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Harish K. The loop stoma bridge - a new technique. J Gastrointest Surg. 2008;12(5):958-961. doi: 10.1007/ s11605-007-0413-7</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Franklyn J, Varghese G, Mittal R, Rebekah G, Jesudason MR, Perakath B. A prospective randomized controlled trial comparing early postoperative complications in patients undergoing loop colostomy with and without a stoma rod. Colorectal Dis. 2017;19(7):675-680. doi: 10.1111/codi.13600</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Lieberman DA, Weiss DG, Harford WV, Ahnen DJ, Provenzale D, Sontag SJ, et al. Five-year colon surveillance after screening colonoscopy. Gastroenterology. 2007;133(4):1077-1085. doi: 10.1053/j.gastro.2007.07.006</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Adegboyega PA, Ololade O, Saada J, Mifflin R, Di Mari JF, Powell DW. Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomas. Clin Cancer Res. 2004;10(17):5870-5879. doi: 10.1158/1078-0432.CCR-0431-03</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Peek RM. Prevention of colorectal cancer through the use of COX-2 selective inhibitors. Cancer Chemother Pharmacol. 2004;54(Suppl 1): S50-S56. doi: 10.1007/s00280-004-0887-x</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Juan TK, Liu KC, Kuo CL, Yang MD, Chu YL, Yang JL, et al. Tetrandrine suppresses adhesion, migration and invasion of human colon cancer SW620 cells via inhibition of nuclear factor-κB, matrix metalloproteinase-2 and matrix metalloproteinase-9 signaling pathways. Oncol Lett. 2018;15(5):7716-7724. doi: 10.3892/ol.2018.8286</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Punganuru SR, Madala HR, Mikelis CM, Dixit A, Arutla V, Srivenugopal KS. Conception, synthesis, and characterization of a rofecoxib-combretastatin hybrid drug with potent cyclooxygenase-2 (COX-2) inhibiting and microtubule disrupting activities in colon cancer cell culture and xenograft models. Oncotarget. 2018;9(40):26109-26129. doi: 10.18632/oncotarget.25450</mixed-citation></ref></ref-list></back></article>
