<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Agronomy and Animal Industries</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Agronomy and Animal Industries</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Агрономия и животноводство</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2312-797X</issn><issn publication-format="electronic">2312-7988</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">19988</article-id><article-id pub-id-type="doi">10.22363/2312-797X-2024-19-1-30-38</article-id><article-id pub-id-type="edn">AJZQTM</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Factors of sustainable animal productivity: from genomics  to therapy</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Факторы устойчивой продуктивности животных: от геномики до терапии</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The influence of mycotoxins on quality indicators of milk in cows in a large livestock complex</article-title><trans-title-group xml:lang="ru"><trans-title>Влияние микотоксинов на качественные показатели молока у коров в условиях крупного животноводческого комплекса</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1007-3441</contrib-id><contrib-id contrib-id-type="spin">2376-1425</contrib-id><name-alternatives><name xml:lang="en"><surname>Gnezdilova</surname><given-names>Larisa A.</given-names></name><name xml:lang="ru"><surname>Гнездилова</surname><given-names>Лариса Александровна</given-names></name></name-alternatives><bio xml:lang="en"><p>Doctor of Veterinary Sciences, Professor, Head of the Department of Disease Diagnostics, Therapy, Obstetrics and Animal Reproduction</p></bio><bio xml:lang="ru"><p>доктор ветеринарных наук, профессор, заведующая кафедрой диагностики болезней, терапии, акушерства и репродукции животных</p></bio><email>lag22004@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0004-3639</contrib-id><contrib-id contrib-id-type="spin">8073-1863</contrib-id><name-alternatives><name xml:lang="en"><surname>Fedotov</surname><given-names>Sergey V.</given-names></name><name xml:lang="ru"><surname>Федотов</surname><given-names>Сергей Васильевич</given-names></name></name-alternatives><bio xml:lang="en"><p>Doctor of Veterinary Sciences, Professor, Department of Disease Diagnostics, Therapy, Obstetrics and Animal Reproduction</p></bio><bio xml:lang="ru"><p>доктор ветеринарных наук, профессор кафедры диагностики болезней, терапии, акушерства и репродукции животных</p></bio><email>serfv@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2516-7627</contrib-id><contrib-id contrib-id-type="spin">4892-9182</contrib-id><name-alternatives><name xml:lang="en"><surname>Muradyan</surname><given-names>Zhora Y.</given-names></name><name xml:lang="ru"><surname>Мурадян</surname><given-names>Жора Юрикович</given-names></name></name-alternatives><bio xml:lang="en"><p>Candidate of Biological Sciences, Associate Professor, Department of Disease Diagnostics, Therapy, Obstetrics and Animal Reproduction</p></bio><bio xml:lang="ru"><p>кандидат биологических наук, доцент кафедры диагностики болезней, терапии, акушерства и репродукции животных</p></bio><email>zh_muradyan@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-1937-6919</contrib-id><contrib-id contrib-id-type="spin">8705-3851</contrib-id><name-alternatives><name xml:lang="en"><surname>Rozinsky</surname><given-names>Serafim M.</given-names></name><name xml:lang="ru"><surname>Розинский</surname><given-names>Серафим Михайлович</given-names></name></name-alternatives><bio xml:lang="en"><p>Assistant, Department of Disease Diagnostics, Therapy, Obstetrics and Animal Reproduction</p></bio><bio xml:lang="ru"><p>ассистент кафедры диагностики болезней, терапии, акушерства и репродукции животных</p></bio><email>s.rozinskii@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Moscow State Academy of Veterinary Medicine and Biotechnology - MVA named after K.I. Skryabin</institution></aff><aff><institution xml:lang="ru">Московская государственная академия ветеринарной медицины и биотехнологии - МВА им. К.И. Скрябина</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-03-15" publication-format="electronic"><day>15</day><month>03</month><year>2024</year></pub-date><volume>19</volume><issue>1</issue><issue-title xml:lang="en">Factors of sustainable animal productivity:  from genomics to therapy</issue-title><issue-title xml:lang="ru">Факторы устойчивой продуктивности животных: от геномики до терапии</issue-title><fpage>30</fpage><lpage>38</lpage><history><date date-type="received" iso-8601-date="2024-04-13"><day>13</day><month>04</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Gnezdilova L.A., Fedotov S.V., Muradyan Z.Y., Rozinsky S.M.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Гнездилова Л.А., Федотов С.В., Мурадян Ж.Ю., Розинский С.М.</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Gnezdilova L.A., Fedotov S.V., Muradyan Z.Y., Rozinsky S.M.</copyright-holder><copyright-holder xml:lang="ru">Гнездилова Л.А., Федотов С.В., Мурадян Ж.Ю., Розинский С.М.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://agrojournal.rudn.ru/agronomy/article/view/19988">https://agrojournal.rudn.ru/agronomy/article/view/19988</self-uri><abstract xml:lang="en"><p style="text-align: justify;">The research was carried out in the dairy complexes of Lednevo breeding farm in the Yuryev- Polsky district, the Vladimirov region. The purpose of the study was to scientifically substantiate the influence of mycotoxins on quality indicators of milk in cows in a large livestock complex. At each of the complexes, 20 cows were selected. The milk samples were taken to determine the content of protein, fat, casein, albumin, globulins, lactose, total solids, dry skimmed milk residue using automatic milk composition analyzer (Combi Milkoscan, FossElectric, Denmark). Analysis of mycotoxin residues in milk was carried out using liquid chromatography mass spectrum. To determine hematological parameters and perform biochemical tests, BioSystemsA25 automatic analyzer (USA) was used. The results of automatic Foss analyzer showed a decrease in dry matter content in milk from cows that received feed with a higher concentration of mycotoxins (10.44 ± 0.22 versus 14.71 ± 0.45 %). Thus, mycotoxins in high concentrations affect amino acid metabolism. Threonine, an essential amino acid obtained from aspartate in bacteria and plants, is metabolized to form glycine and serine, which have a great influence on metabolic processes. Thus, feeding lactating cows with fodder containing mycotoxins reduced feed consumption, milk yield, and also had negative effect on hematological and biochemical blood parameters of experimental cows.</p></abstract><trans-abstract xml:lang="ru"><p style="text-align: justify;">Исследования проводили в молочных комплексах племенного хозяйства ОАО «Леднево» Юрьев- Польского района Владимировской области с целью научного обоснования влияния микотоксинов на качественные показатели молока у коров в условиях крупного животноводческого комплекса. На каждом из комплексов подобрали по 20 коров, у которых брали пробы молока на определение содержания белка, жира, казеина, альбуминов, глобулинов, лактозы, общего количества сухих веществ, сухого обезжиренного молочного остатка с использованием автоматического анализатора состава молока (Combi Milkoscan, FossElectric, Дания). Анализ остатков микотоксинов в молоке проводили с помощью масс-спектр жидкостной хроматографии. Для определения гематологических показателей и проведения биохимических тестов использовали автоматический анализатор BioSystemsA25 (США). Результаты исследования на автоматическом анализаторе Foss показали понижение содержания сухого вещества в молоке от коров, которые получали корма с более высокой концентрацией микотоксинов (10,44 ± 0,22 против 14,71 ± 0,45 %). Следовательно, микотоксины в больших концентрациях влияют на метаболизм аминокислот. Так, треонин - незаменимая аминокислота, получаемая из аспартата бактерий и растений, метаболизируется с образованием глицина и серина, которые имеют большое влияние на метаболический процесс. В период скармливания лактирующим коровам корма, содержащие микотоксины, снижали потребление корма, надои молока, а также оказывали негативное влияние на гематологические и биохимические показатели крови экспериментальных коров.</p></trans-abstract><kwd-group xml:lang="en"><kwd>biochemical test</kwd><kwd>dry matter</kwd><kwd>lactation period</kwd><kwd>amino acid composition</kwd><kwd>liquid chromatography mass spectrum</kwd><kwd>hematological parameters</kwd><kwd>biochemical parameters</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>биохимический тест</kwd><kwd>сухое вещество</kwd><kwd>период лактации</kwd><kwd>аминокислотный состав</kwd><kwd>масс-спектр жидкостной хроматографии</kwd><kwd>гематологические показатели</kwd><kwd>биохимические показатели</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Antipov VA, Miroshnichenko PV, Troshin AN, Shantyz AK. Impact of combined mycotoxins on the body of cattle. Veterinaria i kormlenie. 2016;(2):42–43. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Антипов В.А., Мирошниченко П.В., Трошин А.Н., Шантыз А.Х. Воздействие сочетанных микотоксинов на организм крупного рогатого скота // Ветеринария и кормление. 2016. № 2. С. 42-43.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Kosolapova VG, Khalifa MM, Ishmuratov KG. The impact of mycotoxins on dairy cow health and milk production. Fodder production. 2021;(9):38–46. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Косолапова В.Г., Халифа М.М., Ишмуратов Х.Г. Влияние микотоксинов на здоровье и продуктивность молочного скота // Кормопроизводство. 2021. № 9. С. 38-46.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Gnezdilova LA, Fedotov SV, Muradyan ZY, Rozinsky SM. The influence of mycotoxins on the reproductive and production performance of lactating cows under intensive production conditions. Veterinary, Zootechnics and Biotechnology. 2023;(4):70–80. (In Russ.). doi: 10.36871/vet.zoo.bio.202304007</mixed-citation><mixed-citation xml:lang="ru">Гнездилова Л.А., Федотов С.В., Мурадян Ж.Ю., Розинский С.М. Влияние микотоксинов на репродуктивные и производственные показатели лактирующих коров в условиях интенсивного производства // Ветеринария, зоотехния и биотехнология. 2023. № 4. С. 70-80. doi: 10.36871/vet.zoo.bio.202304007</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Popova SA, Skoptsova TI, Losyakova EV. Mycotoxins in feed: causes, consequences, prevention. Izvestiya of Velikiye Luki State Agricultural Academy. 2017;(1):16–23. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Попова С.А., Скопцова Т.И., Лосякова Е.В. Микотоксины в кормах: причины, последствия, профилактика // Известия Великолукской ГСХА. 2017. № 1. С. 16-23.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Hulik M, Zeman L. Effects of mycotoxin sequestering agents added into feed on health, reproduction and milk yield of dairy cattle. Journal of Dairy and beef cattle breeding. 2016;(4):35–38. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Хулик М., Земан Л. Влияние кормовых агентов, связывающих микотоксины, на здоровье, репродуктивную функцию и молочную продуктивность дойного скота // Молочное и мясное скотоводство. 2016. № 4. С. 35-38.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Hinrich M. Reliable binding of mycotoxins. Kombikorma. 2018;(6):64–66. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Хинрих М. Надежное связывание микотоксинов // Комбикорма. 2018. № 6. С. 64-66.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Soldatenko NA, Drobin YD, Bokun EA, Aliev AY. The presence of mycotoxins in the organs of young animals and poultry at feeding by contaminated with mycotoxins feed. Russian Journal Problems of Veterinary anitation, Hygiene and Ecology. 2020;(4):439–442. (In Russ.). doi: 10.36871/vet.san.hyg.ecol.202004005</mixed-citation><mixed-citation xml:lang="ru">Солдатенко Н.А., Дробин Ю.Д., Бокун Е.А., Алиев А.Ю. Наличие микотоксинов в органах молодняка животных и птиц при скармливании кормов, загрязненных микотоксинами // Российский журнал Проблемы ветеринарной санитарии, гигиены и экологии. 2020. № 4(36). С. 439-442. doi: 10.36871/vet.san.hyg.ecol.202004005</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Antipov VA, Miroshnichenko PV, Troshin AN, Shantyz AK. The impact of combined mycotoxicoses on the body of cattle. Veterinaria i kormlenie. 2016;(2):42–43. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Антипов В.А., Мирошниченко П.В., Трошин А.Н., Шантыз А.Х. Воздействие сочетанных микотоксикозов на организм крупного рогатого скота // Ветеринария и кормление. 2016. № 2. С. 42-43.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Kemboi DC, Antonissen G, Ochieng PE, Croubels S, Okoth S, Kangethe EK, et al. A review of the impact of mycotoxins on dairy cattle health: Challenges for food safety and dairy production in sub-Saharan Africa. Toxins. 2020;12(4):222. doi: 10.3390/toxins12040222</mixed-citation><mixed-citation xml:lang="ru">Kemboi D.C., Antonissen G., Ochieng P.E., Croubels S., Okoth S., Kangethe E.K., Faas J., Lindahl J.F., Gathumbi J.K. A review of the impact of mycotoxins on dairy cattle health: Challenges for food safety and dairy production in sub- Saharan Africa // Toxins. 2020. Vol. 12. № 4. P. 222. doi: 10.3390/toxins12040222</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. Makau CM, Matofari JW, Muliro PS, Bebe BO. Aflatoxin B1 and Deoxynivalenol contamination of dairy feeds and presence of Aflatoxin M1 contamination in milk from smallholder dairy systems in Nakuru, Kenya. International journal of food contamination. 2016;3:6. doi: 10.1186/s40550–016–0033–7</mixed-citation><mixed-citation xml:lang="ru">Makau C.M., Matofari J.W., Muliro P.S., Bebe B.O. Aflatoxin B 1 and Deoxynivalenol contamination of dairy feeds and presence of Aflatoxin M 1 contamination in milk from smallholder dairy systems in Nakuru, Kenya // International journal of food contamination. 2016. No. 3 (1). P. 1-10. doi: 10.1186/s40550-016-0033-7</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Sulzberger SA, Melnichenko S, Cardoso FC. Effects of clay after an aflatoxin challenge on aflatoxin clearance, milk production, and metabolism of Holstein cows. Journal of dairy science. 2017;100(3):1856–1869. doi: 10.3168/jds.2016–11612</mixed-citation><mixed-citation xml:lang="ru">Sulzberger S.A., Melnichenko S., Cardoso F.C. Effects of clay after an aflatoxin challenge on aflatoxin clearance, milk production, and metabolism of Holstein cows // Journal of dairy science. 2017. Vol. 100. № 3. P. 1856-1869. doi: 10.3168/jds.2016-11612</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Valgaeren B, Théron L, Croubels S, Devreese M, De Baere S, Van Pamel E, et al. The role of roughage provision on the absorption and disposition of the mycotoxin deoxynivalenol and its acetylated derivatives in calves: From field observations to toxicokinetics. Archives of toxicology. 2019;93:293–310. doi: 10.1007/s00204–018–2368–8</mixed-citation><mixed-citation xml:lang="ru">Valgaeren B., Théron L., Croubels S., Devreese M., De Baere S., Van Pamel E., Daeseleire E., De Boevre M., De Saeger S., Vidal A., Di Mavungu J.D., Fruhmann P., Adam G., Callebaut A., Bayrou C., Frisée V., Rao A.S., Knapp E., Sartelet A., Pardon B., Deprez P., Antonissen G. The role of roughage provision on the absorption and disposition of the mycotoxin deoxynivalenol and its acetylated derivatives in calves: From field observations to toxicokinetics // Archives of toxicology. 2019. Vol. 93. P. 293-310.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Zhang F, Liu L, Ni S, Deng J, Liu GJ, Middleton R, et al. Turn-on Fluorescence Aptasensor on Magnetic Nanobeads for Aflatoxin M1 Detection Based on an Exonuclease III-Assisted Signal Amplification Strategy. Nanomaterials. 2019;9(1):104. doi: 10.3390/nano9010104</mixed-citation><mixed-citation xml:lang="ru">Zhang F., Liu L., Ni S., Deng J., Liu G.-J., Middleton R., Inglis D.W., Wang S., Liu G. Turn-on Fluorescence Aptasensor on Magnetic Nanobeads for Aflatoxin M1 Detection Based on an Exonuclease III-Assisted Signal Amplification Strategy // Nanomaterials. 2019. Vol. 9. № 1. Р. 104. doi: 10.3390/nano9010104</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Gao Y, Li S, Wang J, Luo C, Zhao S, Zheng N. Modulation of Intestinal Epithelial Permeability in Differentiated Caco‑2 Cells Exposed to Aflatoxin M1 and Ochratoxin A Individually or Collectively. Toxins. 2018;10(1):13. doi: 10.3390/toxins10010013</mixed-citation><mixed-citation xml:lang="ru">Gao Y., Li S., Wang J., Luo C., Zhao S., Zheng N. Modulation of Intestinal Epithelial Permeability in Differentiated Caco-2 Cells Exposed to Aflatoxin M1 and Ochratoxin a Individually or Collectively // Toxins. 2018. Vol. 10. № 1. Р. 13. doi: 10.3390/toxins10010013</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Ahn JY, Kim J, Cheong DH, Hong H, Jeong JY, Kim BG. An In Vitro Study on the Efficacy of MycotoxinSequestering Agents for Aflatoxin B1, Deoxynivalenol, and Zearalenone. Animals. 2022;12(3):333. doi: 10.3390/ani12030333</mixed-citation><mixed-citation xml:lang="ru">Ahn J.Y., Kim J., Cheong D.H., Hong H., Jeong J.Y., Kim B.G. An In Vitro Study on the Efficacy of Mycotoxin Sequestering Agents for Aflatoxin B1, Deoxynivalenol, and Zearalenone // Animals. 2022. Vol. 12. № 3. Р. 333. doi: 10.3390/ani12030333</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Xiong JL, Wang YM, Nennich TD, Li Y, Liu JX. Transfer of dietary aflatoxin B1 to milk aflatoxin M1 and effect of inclusion of adsorbent in the diet of dairy cows. Journal of Dairy Science. 2015;98(4):2545–2554. doi: 10.3168/jds.2013–7842</mixed-citation><mixed-citation xml:lang="ru">Xiong J.L., Wang Y.M., Nennich T.D., Li Y., Liu J.X. Transfer of dietary aflatoxin B1 to milk aflatoxin M1 and effect of inclusion of adsorbent in the diet of dairy cows // Journal of Dairy Science. 2015. Vol. 98. № 4. P. 2545-2554. doi: 10.3168/jds.2013-7842</mixed-citation></citation-alternatives></ref></ref-list></back></article>
