The results of prooxidant-­antioxidant control of the efficiency of various schemes of aerosol complex therapy for acute catarrhal bronchopneumonia in calves using the generally accepted scheme (aerosol treatment indoors with iodotriethyleneglycol solution with intramuscular administration of the drug ”Penstrep‑400“), as well as schemes proposed by us, based on previously conducted studies to determine the sensitivity of isolated microflora to antibacterial drugs (aerosol treatment indoors with iodotriethyleneglycol solution with intramuscular administration of the drug ”Marfloxacin“) and phytobiotics (aerosol treatment indoors with Hypericum perforatum wort extract with intramuscular administration of the drug ”Marfloxacin“) were presented. Black-and-white calves, aged 1–3 months, mixed sex, with clinical signs of acute catarrhal bronchopneumonia were studied. The sick animals were divided into three experimental groups using the envelope method: ₁O — experimental 1, n = 20; ₂O — experimental group 2, n = 20 and ₃O — experimental group 3, n = 20 and placed in separate isolators. During the treatment of animals in group ₁O, the general clinical improvement occurred only on the 9.25 ± 0.91 day, while six cases of complications occurred, and two animals died. The treatment of calves in group ₂O was accompanied by the general clinical improvement 2.05 days earlier, compared with group ₁O, and all animals recovered. Therapy in group ₃O contributed to the general clinical improvement already on the 4.90 ± 0.64 day, which is 47.0% earlier compared with the indicators of group ₁O, and all 20 calves also recovered. The study of the processes of lipid peroxidation and antioxidant protection in blood plasma of experimental calves in the dynamics of treatment confirmed the best result in ₃O group, which was accompanied by a significant decrease in LPO products and an increase in AOS indicators, which already on the 7th day of observation approached the physiological norm.