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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">RUDN Journal of Agronomy and Animal Industries</journal-id><journal-title-group><journal-title xml:lang="en">RUDN Journal of Agronomy and Animal Industries</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Российского университета дружбы народов. Серия: Агрономия и животноводство</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2312-797X</issn><issn publication-format="electronic">2312-7988</issn><publisher><publisher-name xml:lang="en">Peoples’ Friendship University of Russia named after Patrice Lumumba</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">20204</article-id><article-id pub-id-type="doi">10.22363/2312-797X-2025-20-2-323-332</article-id><article-id pub-id-type="edn">ODGYVF</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Veterinary science</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Ветеринария</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Immunological parameters in serous catarrhal inflammation of the udder in lactating cows</article-title><trans-title-group xml:lang="ru"><trans-title>Иммунологические показатели при серозно-катаральном воспалении вымени у лактирующих коров</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2996-0991</contrib-id><contrib-id contrib-id-type="spin">3038-0685</contrib-id><name-alternatives><name xml:lang="en"><surname>Ostyakova</surname><given-names>Marina E.</given-names></name><name xml:lang="ru"><surname>Остякова</surname><given-names>Марина Евгеньевна</given-names></name></name-alternatives><bio xml:lang="en"><p>Doctor of Biological Sciences, Associate Professor, Director</p></bio><bio xml:lang="ru"><p>доктор биологических наук, доцент, директор</p></bio><email>dalznividv@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-6247-0280</contrib-id><contrib-id contrib-id-type="spin">9056-4692</contrib-id><name-alternatives><name xml:lang="en"><surname>Kositsyna</surname><given-names>Ksenia S.</given-names></name><name xml:lang="ru"><surname>Косицына</surname><given-names>Ксения Сергеевна</given-names></name></name-alternatives><bio xml:lang="en"><p>Junior Researcher, Department of Microbiology, Virology and Immunology, Far Eastern Zone Research Veterinary Institute; Assistant of the Department of Veterinary and Sanitary Expertise, Epizootology and Microbiology, Far Eastern State Agrarian University</p></bio><bio xml:lang="ru"><p>младший научный сотрудник отдела микробиологии, вирусологии и иммунологии, Дальневосточный зональный научно-исследовательский ветеринарный институт; ассистент кафедры ветеринарносанитарной экспертизы, эпизоотологии и микробиологии, Дальневосточный государственный аграрный университет</p></bio><email>kseniya-kos1997@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4553-7189</contrib-id><contrib-id contrib-id-type="spin">7893-0109</contrib-id><name-alternatives><name xml:lang="en"><surname>Irkhin</surname><given-names>Vera K.</given-names></name><name xml:lang="ru"><surname>Ирхина</surname><given-names>Вера Константиновна</given-names></name></name-alternatives><bio xml:lang="en"><p>Researcher of the Department of Animal Husbandry and Poultry Farming</p></bio><bio xml:lang="ru"><p>научный сотрудник отдела животноводства и птицеводства</p></bio><email>dalznividv@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Far East Zone Research Veterinary Institute</institution></aff><aff><institution xml:lang="ru">Дальневосточный зональный научно-исследовательский ветеринарный институт</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Far Eastern State Agrarian University</institution></aff><aff><institution xml:lang="ru">Дальневосточный государственный аграрный университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-08-01" publication-format="electronic"><day>01</day><month>08</month><year>2025</year></pub-date><volume>20</volume><issue>2</issue><issue-title xml:lang="en">Applied aspects of pharmaceutical science in veterinary medicine</issue-title><issue-title xml:lang="ru">Прикладные факторы рынка лекарственных средств</issue-title><fpage>323</fpage><lpage>332</lpage><history><date date-type="received" iso-8601-date="2025-08-13"><day>13</day><month>08</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Ostyakova M.E., Kositsyna K.S., Irkhin V.K.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Остякова М.Е., Косицына К.С., Ирхина В.К.</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Ostyakova M.E., Kositsyna K.S., Irkhin V.K.</copyright-holder><copyright-holder xml:lang="ru">Остякова М.Е., Косицына К.С., Ирхина В.К.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://agrojournal.rudn.ru/agronomy/article/view/20204">https://agrojournal.rudn.ru/agronomy/article/view/20204</self-uri><abstract xml:lang="en"><p>The aim of this study is to investigate the immunological parameters of blood in lactating cows with serous-catarrhal mastitis to identify the pathogenetic mechanisms of the disease. The research was carried out in autumn in one of the livestock farms of the Amur region. The object of the study was lactating cows of Holstein breed at 2-4 months of lactation. Groups of cows were formed by 10 animals in each: control (healthy) and experimental (sick with serous catarrhal mastitis). The inflammatory process in the mammary gland of lactating cows was caused by tissue damage and complicated by opportunistic microflora. Protein metabolism disorders (hypoalbuminemia, dysproteinemia) and signs of haemoconcentration (increased haematocrit and haemoglobin, erythrocytosis) were observed in sick animals. Conditionally pathogenic microflora and products of inflammation in the mammary gland stimulated cellular and humoral immunity.</p></abstract><trans-abstract xml:lang="ru"><p>Целью исследования является изучение иммунологических параметров крови у лактирующих коров при серозно-катаральном воспалении вымени для выявления патогенетических механизмов заболевания. Исследования проводили осенью в одном из животноводческих хозяйств Амурской области. Объект исследования - лактирующие коровы голштинской породы на 2-4 мес. лактации. Группы коров формировали по 10 голов в каждой: контрольная (здоровые) и опытная (больные серозно-катаральным маститом). Воспалительный процесс в молочной железе лактирующих коров был обусловлен повреждением тканей и осложнен условно-патогенной микрофлорой. У больных животных отмечали нарушения белкового обмена (гипоальбуминемия, диспротеинемии) и признаки гемоконцентрации (повышенный гематокрит и гемоглобин, эритроцитоз). Условно-патогенная микрофлора и продукты воспаления в молочной железе стимулировали клеточный и гуморальный иммунитет.</p></trans-abstract><kwd-group xml:lang="en"><kwd>mammary gland inflammation</kwd><kwd>biochemical and immunological blood parameters</kwd><kwd>immunity</kwd><kwd>dairy cattle</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>воспаление молочной железы</kwd><kwd>биохимические показатели крови</kwd><kwd>иммунологические показатели крови</kwd><kwd>иммунитет</kwd><kwd>молочный скот</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Petrova ZA. Ehksperimental’nye issledovaniya po ehffektivnosti lecheniya korov bol’nykh sublinicheskim mastitom preparatami, ne soderzhashchimi antibiotiki [Experimental studies on the effectiveness of treatment of cows with sublunar mastitis with preparations that do not contain antibiotics]. 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