RUDN Journal of Agronomy and Animal Industries
type: channel
description: Editor-in-Chief: Yuri A. Vatnikov, Doctor of Veterinary Sciences, Professor ISSN: 2312-797Х (Print) ISSN: 2312-7988 (Online) Indexation: White List, Russian Index of Science Citation, RSCI, CABI, AGRIS, WJCI, Google Scholar, Ulrich's Periodicals Directory, WorldCat, Cyberleninka, DOAJ, Dimensions, ResearchBib, Research4Life, Lens, JournalTOCs Founded in 2006. Publication frequency: quarterly. Publication language: Russian, English Peer-Review: double blind. Open Access: Open Access. APC: no article processing charge. PUBLISHER: Peoples’ Friendship University of Russia named after Patrice Lumumba (RUDN University)
publisher: Peoples’ Friendship University of Russia named after Patrice Lumumba
language: ru-RU
publication name: RUDN Journal of Agronomy and Animal Industries
issn: 2312-797X
copyright: The right of authorship belongs to the authors of articles. The authors transfer the rights to use the article (including the use and distribution of an article in the Open Access) to the publisher of the journal on a non-exclusive license (Publishing Agreement (Public Offer)). At the same time, authors remain full rightsholders. Publishing Agreement (Public Offer) to Publish an Article in an Academic Periodical "RUDN Journal of Agronomy and Animal Indastries" The Federal State Autonomous Educational Institution of Higher Education "Peoples’ Friendship University of Russia named after Patrice Lumamba” (RUDN University), represented by the Vice-Rector for Scientific Work Andrey Aleksandrovich Kostin, acting under a Power of Attorney No 0044-09/20-198 dated 29.07.2020, hereinafter referred to as the Publisher, on the one hand, hereby offers to the public at large, hereinafter referred to as the Author, on the other hand, hereinafter collectively referred to as the Parties, to enter into this agreement, hereinafter referred to as the Agreement, regarding publication of scholarly materials, hereinafter referred to as the Article, in the Journal named 'RUDN Journal of Agronomy and Animal Industries', hereinafter referred to as the Journal, under the following terms. 1. General Terms and Conditions 1.1. Pursuant to Clause 2 of the Article 437 of the Russian Federation Civil Code, this Agreement shall be recognized as the public offer, hereinafter referred to as the Offer. Subject to Article 438 of the Russian Federation Civil Code, this Offer shall be deemed to have been completely and irrevocably accepted after the Author had submitted his/her materials by uploading those onto the network electronic system of the article acquisition for review available at the respective section of the Journal's site at URL:http://journals.rudn.ru/index.php/agronomy/author/submit/1 on the Information and Communication Network known as the Internet, hereinafter referred to as the Internet…
items: From the editorial
items: Introduction and biochemical composition of Chrysanthemum coronarium L. in Non-­Chernozem regions
items: Status and forecast of changes in areas under vegetable crops and drip irrigation in the Republic of Crimea
items: Effect of light on growth rate, development and yield of spring rapeseed
items: Cultivation of soybeans using strip-till technology in the Pre-­Caucasian region
items: Identification of genes for resistance to leaf and stem rust in breeding lines of spring common wheat from the secondary gene pool of Arsenal collection
items: Assessment of soil fertility in arctic cities using the soil-ecological index
items: Agrochemical assessment of the effect of vermiculite on reducing ammonium ion mobility
items: Application of various methods for studying the secretion of the bovine mammary gland in the diagnosis of mastitis
items: Features of the occurrence, spread, diagnosis, pathogenesis and treatment of infectious feline peritonitis
items: Methodological basis for implantation of a cementless femoral component in canine total hip replacement
items: Comparative efficacy of multikinase inhibitors in the treatment of squamous cell carcinoma in cats
items: The effect of Rhodiola Rosea and Leuzea carthamoides on the antibiotic resistance of E. coli

From the editorial
type: item
description: -
creator: Yu. A. Vatnikov
rights: Copyright (c) 2026 Vatnikov Y.A. https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-25
publication date: 2026-02-25
volume: 20
number: 4
starting page: 517
ending page: 520
doi: 10.22363/2312-797X-2025-20-4-517-520

Introduction and biochemical composition of Chrysanthemum coronarium L. in Non-­Chernozem regions
type: item
description: This study discusses the introduction and adaptation of edible chrysanthemum (Chrysanthemum coronarium L.) in the Non-­Chernozem Zone of the Russian Federation. The focus is on studying the plant’s biochemical composition, nutritional value, and pharmacological properties. Data on high content of vitamins, minerals, antioxidants, and other bioactive substances such as flavonoids and amino acids are presented. The influence of growing conditions, including lighting regimes and salt stress, on the accumulation of beneficial components in the plant is examined. The importance of further research to optimize agricultural practices and assess the economic viability of cultivating Chrysanthemum coronarium L. in this region is emphasized.
creator: Elena V. Romanova
creator: Murat S. Gins
creator: Valentina K. Gins
creator: Parfait Kesimana
creator: Eriсkson Tchuda Lopes Mam
rights: Copyright (c) 2026 Romanova E.V., Gins M.S., Gins V.K., Kesimana P., Tchuda Lopes Mam E. https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-25
publication date: 2026-02-25
volume: 20
number: 4
starting page: 521
ending page: 530
doi: 10.22363/2312-797X-2025-20-4-521-530

Status and forecast of changes in areas under vegetable crops and drip irrigation in the Republic of Crimea
type: item
description: The purpose of the research was to assess the current state of vegetable growing in the Republic of Crimea to determine vegetable demand and to calculate the prospects for the development of vegetable growing considering the current economic conditions and changes in the area irrigated by drip systems in order to increase vegetable production, reduce its production cost through efficient use of water resources, preserve and improve fertility of reclaimed lands. Statistical data on the area and productivity of vegetable crops, the dynamics of mineral fertilizer application for vegetables and the number of sprinkler equipment in 2015–2023 in the Republic of Crimea were used. The analysis of changes in the current state of the area cultivated for vegetable crops in the Republic of Crimea revealed a negative trend. During 2015–2023, there was a steady decrease in the area from 7.3 to 5.8 thousand hectares. Against this background, the volume of vegetable production varied from 173.0 to 204.8 thousand tons. At the same time, there has been a reduction in the number of sprinklers and installations from 556 in 2016 to 384 in 2023. There was instability in the amount of mineral fertilizers used for vegetable crops, so in 2020, 179 tons of mineral fertilizers were applied, and in 2023 this figure was 265 tons. The volume of vegetable products produced does not cover the needs of the population of the Republic of Crimea by an average of 61.46 thousand tons. Despite the Republic is a resort region, by the end of 2024, the needs of tourists during the resort season alone were not met by 740.1 thousand tons. However, our forecast shows that based on the available data, by 2030 the area under vegetable crop cultivation may decrease to 3.8 thousand hectares. At the same time, according to the forecast, the irrigated area equipped with drip irrigation may increase from 16.7 thousand hectares in 2023 to 22.1 thousand hectares by 2030, and to 29.5 thousand hectares by 2040. In this r…
creator: Dmitry Petrovich Sidarenko
creator: Petr Vasilyevich Sidarenko
rights: Copyright (c) 2026 Sidarenko D.P., Sidarenko P.V. https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-25
publication date: 2026-02-25
volume: 20
number: 4
starting page: 531
ending page: 544
doi: 10.22363/2312-797X-2025-20-4-531-544

Effect of light on growth rate, development and yield of spring rapeseed
type: item
description: Spring rapeseed is one of the most important oilseed crops worldwide. Currently, one rapeseed development cycle takes about five to six months. Shortening the growing season can significantly reduce the growing period and speed up the realization of breeding and research projects. This could allow up to four generations of rapeseed instead of two or three under greenhouse conditions. Our research was conducted in 2023–2024 in a two-section climatic chamber developed at Federal Scientific Agroengineering Center VIM. The aim of the study was to study the effect of accelerating the growing season of rape by increasing the photoperiod and using different spectral composition of light. The experiment was conducted in 4 variants: Variant 1 (22/2 RB) — photoperiod 22 h day / 2 h night and spectral composition R:40/B:60 (red-blue spectrum only); Variant 2 (22/2 FS) — photoperiod 22 h day / 2 h night and full spectrum FS (UV0.5: B37: G6.5: Y3: R49: FR4); Variant 3 (16/8 RB) — photoperiod 16 h / 8 h night and spectral composition R:40/B:60 (red-blue spectrum only); Variant 4 (16/8 FS) (control) — photoperiod 16 h day / 8 h night and full spectrum (UV0.5: B37: G6.5: Y3: R49: FR4). We achieved a reduction in growing season by 14 days using an extended photoperiod (22-hour daylight hours) and full spectrum radiation (UV0.5: B37: G6.5: Y3: R49: FR4). It was found that variants 1 and 2 used in the experiment could be used to obtain rape seeds of proper quality. The best was variant 2–22/2 FS using 22 hour daylight hours and full spectrum radiation (UV0.5: B37: G6.5: Y3: R49: FR4).
creator: Maria Sergeevna Shirokova
creator: Andrey Alexandrovich Grishin
creator: Artem Alexandrovich Dorokhov
creator: Elena Valerievna Pavlova
creator: Nadezhda Igorevna Uyutova
rights: Copyright (c) 2026 Shirokova M.S., Grishin A.A., Dorokhov A.A., Pavlova E.V., Uyutova N.I. https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-25
publication date: 2026-02-25
volume: 20
number: 4
starting page: 545
ending page: 565
doi: 10.22363/2312-797X-2025-20-4-545-565

Cultivation of soybeans using strip-till technology in the Pre-­Caucasian region
type: item
description: The results of research on the use of the original Strip-­Till technology in cultivation of soybeans on the southern chernozem in the zone of unstable moisture in the southeastern part of the Stavropol Territory are presented, since the production of protein products is aimed at reducing production and energy costs. Moreover, the most promising option for this technology is the separate formation of treated soil strips in autumn and sowing seeds with a special seed drill in spring, in contrast to combined spring sowing. The originality of the approach in research on this technology, in contrast to the classically accepted Strip-­Till technology for row crops, lies in the preliminary use of disc soil tillage combined with post-stubble application of a systemic herbicide to create a soil-and-stubble mulch that serves as a protective barrier against soil moisture evaporation. According to the results of the conducted studies, a greater (by 10.1%) number of agronomically valuable aggregates of 10–0.25 mm, and a higher coefficient (by 0.9 units) of structurality were found during soil cultivation with a cultivator-­slitter compared to moldboard plowing. Corresponding to the smaller mean-weighted aggregate diameter under the Strip-­Till technology versus plowing (1.3 mm) during the spring growing season is a higher soil density (by 0.02 g/cm³) and, consequently, a higher capillary porosity (by 4%). With an increase in the volume (20.6%) of capillary pores along the cultivator row under the Strip-­Till technology during the spring growing season, the reserve of productive moisture also increased — by 6 mm compared with conventional tillage. Therefore, the value of the fractal geometry index D = 0.93 for the Strip-­Till technology is higher in comparison with conventional technology (D = 0.77). A significant increase in soybean yield was also noted — by 0.13 t/ha — with profitability of 163%, while production costs decreased by 4%.
creator: Yuri Alekseevich Kuzychenko
rights: Copyright (c) 2026 Kuzychenko Y.A. https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-25
publication date: 2026-02-25
volume: 20
number: 4
starting page: 566
ending page: 576
doi: 10.22363/2312-797X-2025-20-4-566-576

Identification of genes for resistance to leaf and stem rust in breeding lines of spring common wheat from the secondary gene pool of Arsenal collection
type: item
description: Leaf rust (Puccinia triticina Eriks.) and stem rust (Puccinia graminis f. sp. tritici) are the main causes of declining wheat yields in Russia and abroad. Epidemics of these diseases lead to significant economic losses. In recent years, there has been increased pressure from new, more aggressive races of pathogens. As a result, a breeding strategy aimed at protecting wheat varieties from these diseases is extremely relevant and a priority. The aim of this work was to identify effective and partially effective genes of resistance to leaf (Lr19, Lr24, Lr26, Lr29, Lr34, Lr37) and stem (Sr17, Sr22, Sr36, Sr39, Sr47) rust in the Ob forest-­steppe of the Altai Territory for the further development of a set of breeding measures aimed at creating new varieties of spring wheat with resistance to rust diseases in local conditions using modern methods of molecular marker selection. The material for the study was 25 promising lines of spring common wheat of secondary origin from Arsenal collection (Nemchinovka Research Center) with group resistance to leaf-stem diseases and having genetic material of the species Aegilops speltoides, Ae. triuncialis, Triticum kiharae, Secale cereale and T. migushovae in the pedigree. Molecular analysis made it possible to determine effective Lr genes in 80 %, and Sr genes in all tested accessions. The largest number of identified genes (5–6) were found in the following lines: 5–16i, 20–16i, 34–16i, 44–16i, 45–16i, 48–16i, 53–16i, and the smallest (2–3) in: 1–16i, 14–16i, 19–16i, 21–16i, 25–16i, 40–16i, 49–16i, 61–16i and 135/10i. The desired Lr genes were not found in accessions 1–16i, 28–16i, 49–16i, 61–16i. The results of the studies showed the presence of a wide range of genes of resistance to leaf and stem rust, which indicates the donor properties of the lines of Arsenal collection and the possibility of their effective use in marker associated selection in the development of wheat varieties resistant to rust diseases.
creator: Vadim A. Petin
creator: Sergey B. Lepekhov
creator: Inna F. Lapochkina
creator: Nail R. Gainullin
rights: Copyright (c) 2026 Petin V.A., Lepekhov S.B., Lapochkina I.F., Gainullin N.R. https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-25
publication date: 2026-02-25
volume: 20
number: 4
starting page: 577
ending page: 588
doi: 10.22363/2312-797X-2025-20-4-577-588

Assessment of soil fertility in arctic cities using the soil-ecological index
type: item
description: The fertility of urban soils in the Arctic is limited by harsh climatic conditions and high anthropogenic pressure. In addition to the typical impacts of residential use, recreation, and transportation common in any urbanized areas, the ecosystems of Russian Arctic cities are subject to the technogenic influence of heavy industry hubs, which often serve as the foundation for these cities. Under such conditions, the soil cover of the largest cities in the Russian Arctic — Murmansk, Vorkuta, and Norilsk — has formed. An analysis of the physical and chemical properties of urban soils, an assessment of their fertility, and the limiting factors are necessary for the creation and maintenance of urban green infrastructure, which is one of the key factors in the ecological comfort of city life. This study evaluates the acidity, organic matter and total nitrogen content, availability of mobile forms of phosphorus and potassium in the topsoil of these cities and provides an integrated assessment of their fertility based on the soil-ecological index (SEI) by I.I. Karmanov, adapted within the study for application to northern soils and territories. It is shown that, based on the combination of indicators, the soils of the studied sites form the sequence Murmansk > Vorkuta > Norilsk, from the most fertile to the least fertile. The influence of anthropogenic factors on soil properties is noted, which can be both positive (a decrease in average soil acidity across all sites) and negative (toxic concentrations of mobile phosphorus in the soils of Murmansk). Based on the obtained SEI values, it is concluded that the soils of the studied sites have relatively high overall fertility, comparable to that of soils in the middle and southern taiga.
creator: Artem I. Losev
creator: Vyacheslav I. Vasenev
creator: Egor D. Berezhnoy
creator: Yulia L. Sotnikova
rights: Copyright (c) 2026 Losev A.I., Vasenev V.I., Berezhnoy E.D., Sotnikova Y.L. https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-25
publication date: 2026-02-25
volume: 20
number: 4
starting page: 589
ending page: 605
doi: 10.22363/2312-797X-2025-20-4-589-605

Agrochemical assessment of the effect of vermiculite on reducing ammonium ion mobility
type: item
description: An agrochemical assessment of the effect of expanded vermiculite on reducing ammonium ions mobility was carried out using methods of phytotesting soil mixtures with determination of nitrogen forms. The studies were conducted using urea, which was added in granular or dissolved form in a wide range of nitrogen dose values, including those exceeding the maximum permissible concentration. We used two types of soil, which differ in the content of the organic component. It has been shown that expanded vermiculite effectively reduces the content of the exchangeable form of ammonium; fixed ammonium turns into the nitrate form more slowly compared to exchangeable ammonium.
creator: Irina P. Kremenetskaya
creator: Marina V. Slukovskaya
creator: Liubov A. Ivanova
creator: Maria A. Yartseva
creator: Tatiana K. Ivanova
rights: Copyright (c) 2026 Kremenetskaya I.P., Slukovskaya M.V., Ivanova L.A., Yartseva M.A., Ivanova T.K. https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-25
publication date: 2026-02-25
volume: 20
number: 4
starting page: 606
ending page: 617
doi: 10.22363/2312-797X-2025-20-4-606-617

Application of various methods for studying the secretion of the bovine mammary gland in the diagnosis of mastitis
type: item
description: The study presents data on the analysis of the application of various methods for examining mammary gland secretions in cows for the diagnosis of mastitis. The studies were conducted during 2023. The object of the study was lactating cows and the secretion of their mammary gland. The prevalence of mastitis in cows during the study was 36.6%; during the repeated examination, the number of animals with latent inflammation of the mammary gland increased by 3.4%. At the time of the first examination, 63.3% of cows had milk of the highest grade in terms of somatic cell (SC) count (up to 250 thousand cells/ml). In 8.3% of cows with clinical mastitis, an increase in SC count over 750 thousand cells/ml was recorded. The minimum lactoferrin concentration in mammary gland secretions during the first examination was 0.25 mg/ml, and the maximum was 3.5 mg/ml; the mean value was 1.62 mg/ml. During the second examination, an increase in both the minimum and maximum lactoferrin concentrations was observed, reaching 0.69 mg/ml and 4.1 mg/ml, respectively. At the time of the initial study, the maximum deviation of urea concentration from reference values in the mammary gland secretion of cows was 35.15 ± 0.45 mg/100 ml, and the minimum was 14.18 ± 0.18 mg/100 ml. During the repeated examination, the proportion of cows showing deviations from reference urea values (either decreased or increased) was 38.3%, and 46.7% after 7 days. Microbiological analysis of mammary gland secretions revealed the following microorganisms: coliform bacteria (38.9%), Staphylococcus aureus (38.9%), Enterococcus faecalis (22.2%), using the cultural research method; taphylococcus spp. (55.6%), S. aureus (22.2%), and Escherichia coli (22.2%) using PCR, with repeated testing showing the presence of Pseudomonas aeruginosa in 46.2% of samples; and Streptococcus dysgalactiae (36.4%), Staphylococcus epidermidis (18.2%), Aerococcus viridans (18.2%), S. aureus (9.1%), Staphylococcus haemolyticus (9.1%) and Coryneba…
creator: Maria Nikolaevna Isakova
creator: Natalya Aleksandrovna Bezborodova
creator: Yana Yuryevna Lysova
creator: Olga Yuryevna Oparina
rights: Copyright (c) 2026 Isakova M.N., Bezborodova N.A., Lysova Y.Y., Oparina O.Y. https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-25
publication date: 2026-02-25
volume: 20
number: 4
starting page: 618
ending page: 634
doi: 10.22363/2312-797X-2025-20-4-618-634

Features of the occurrence, spread, diagnosis, pathogenesis and treatment of infectious feline peritonitis
type: item
description: This study presents a synthesis of current data on the prevalence, pathogenesis, diagnosis, and treatment of feline infectious peritonitis (FIP), caused by feline coronavirus (FCoV). Coronaviruses are characterized by a high mutation rate and the ability to cross species barriers, which explains their wide distribution among domestic and wild animals. It has been established that FCoV is detected in a significant proportion of the feline population; however, infectious peritonitis develops in only about 10 % of infected animals as a result of viral mutations occurring within the host organism. The disease is accompanied by systemic inflammatory processes, multiple organ failure, and high mortality. The study examines the mechanisms of coronavirus transmission, including the role of bats as reservoirs of α- and β-­CoVs, and confirms the ability of SARS-CoV-2 to replicate in cats and dogs, indicating potential zoonotic risks. Particular attention is given to laboratory diagnostic approaches, including PCR, ELISA, and the detection of characteristic biochemical and morphological changes. Data on lesions affecting various organs and systems are summarized, with a focus on cardiovascular complications, including myocarditis, which may develop either as a result of direct myocardial infection by the virus or secondary to systemic inflammatory responses and cytokine storm. Modern therapeutic strategies, including antiviral and immunomodulatory approaches, are analyzed. Nucleoside analogues, particularly GS-441524, which inhibits viral RNA replication, are highlighted as the most promising. The emergence of Russian drugs such as “KoronaCat” and “Melon-­V” has been noted; however, the risk of resistant strain development remains a concern. Thus, feline infectious peritonitis continues to represent one of the most pressing problems in veterinary medicine. The systematization of available data underscores the need for further studies aimed at clarifying the pathogenesis, impro…
creator: Sergey Vladimirovich Laptev
creator: Marina Viktorovna Selina
rights: Copyright (c) 2026 Laptev S.V., Selina M.V. https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-25
publication date: 2026-02-25
volume: 20
number: 4
starting page: 635
ending page: 644
doi: 10.22363/2312-797X-2025-20-4-635-644

Methodological basis for implantation of a cementless femoral component in canine total hip replacement
type: item
description: Total hip replacement in dogs is an effective method for treating various pathologies of the hip joint. However, the problem of aseptic instability of the femoral component in the postoperative period persists. An analysis of 227 surgeries using the Russian cementless system V@art was conducted. This system was developed based on Swiss KYON technology but incorporates a number of improvements: a monolithic stem made of Ti6Al4V ELI titanium alloy, a double-lead conical thread for the fixation screws, and an optimized protocol for their placement. The results demonstrate that the modified implantation protocol for the V@art system ensures reliable osseointegration as early as 45 days postoperatively, reduces the cost of the intervention, and minimizes risks. The system can be considered a promising alternative to foreign analogues in veterinary practice within the Russian Federation.
creator: Andrey M. Pantiulin
creator: Ilya F. Vilkovyskiy
rights: Copyright (c) 2026 Pantiulin A.M., Vilkovyskiy I.F. https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-25
publication date: 2026-02-25
volume: 20
number: 4
starting page: 645
ending page: 657
doi: 10.22363/2312-797X-2025-20-4-645-657

Comparative efficacy of multikinase inhibitors in the treatment of squamous cell carcinoma in cats
type: item
description: The use of tyrosine kinase inhibitors (TKIs) in the treatment of oncological patients is reviewed. Feline oral squamous cell carcinoma (FOSCC) is locally aggressive disease affecting the epithelium. It can rapidly metastasise to soft tissues and bone structures, causing severe pain and loss of function in affected organs. Recently, tyrosine kinase inhibitors, for example, drugs with active substance toceranib were used for the implementation of anti-cancer treatment in veterinary medicine. Currently, toceranib phosphate (commercial drug Palladia) is unavailable in Russia, making the use of drugs with similar mechanisms of action highly relevant. The aim of the study was to compare the efficacy of toceranib and sorafenib tyrosine kinase inhibitors in the treatment of FOSCC. The object of the study was 30 cats of different breeds with confirmed FOSCC. The diagnosis was established based on physical examination and results of cytological and histological studies. Computer tomography (CT) was performed to determine tumour localisation and lymph node involvement. The animals were divided into three groups: group 1 received sorafenib, group 2 received toceranib, and group 3 (control) received no anticancer therapy. Some cats in groups 1 and 2 underwent surgical treatment as indicated. The study assessed overall survival time and time to progression. According to the results of the study, the average life expectancy of animals in group 1 was 112.4 ± 29.1 days, in 2 — 98.1 ± 18.8 days, in 3 — 24.2 ± 3.6 days. The average duration of the non-recurrence period in the group 1 is 85,3 ± 17.1 days, in the group 2 — 86.8 ± 13.0 days. Therefore, In the treatment of head-region SCC in cats, sorafenib demonstrates efficacy comparable to that of toceranib and may serve as a substitute on the Russian market. Moreover, modelling anticancer therapy in small companion animals may inform the development of treatment protocols for human oncological patients.
creator: Boris Stepanovich Semenov
creator: Anna Veniaminovna Nazarova
creator: Tatyana Shamilevna Kuznetsova
rights: Copyright (c) 2026 Semenov B.S., Nazarova A.V., Kuznetsova T.S. https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-25
publication date: 2026-02-25
volume: 20
number: 4
starting page: 658
ending page: 669
doi: 10.22363/2312-797X-2025-20-4-658-669

The effect of Rhodiola Rosea and Leuzea carthamoides on the antibiotic resistance of E. coli
type: item
description: Bacteria are constantly evolving, becoming resistant to antibiotics. Antimicrobial resistance is a complex problem arising from the adaptive capabilities of bacteria and their rapid spread among microorganisms, making the treatment of infections increasingly difficult. Escherichia coli is a bacterium of the Enterobacteriaceae family, it has clinical and epidemiological significance. The bacterium is one of the reservoirs for antibiotic resistance genes and for this reason has been classified by the World Health Organization as a pathogen posing a threat to public health. Herbal medicines and their components possess properties that can alter the resistance of microorganisms to antimicrobial drugs. The effect of plant adaptogens on the resistance of microorganisms to antibiotics is insufficiently studied. An in vitro study was conducted to examine the impact of Rhodiola rosea and Leuzea carthamoides on the susceptibility level of Escherichia coli to various antimicrobial drugs. Escherichia coli cultures were obtained from calves with symptoms of acute intestinal diseases. Susceptibility to 12 antimicrobial drugs from five groups was determined, including penicillins, carbapenems, cephalosporins, aminoglycosides, and fluoroquinolones. The effect of Rhodiola rosea and Leuzea carthamoides was studied by co-incubating Escherichia coli cultures with a decoction of adaptogen roots, followed by re-culturing the isolates and re-determining susceptibility. The results showed that after exposure to Rhodiola rosea and Leuzea carthamoides, the resistance of Escherichia coli to cephalosporins (ceftazidime, ceftriaxone, and cefixime) decreased by 3–43%, depending on the antimicrobial drug and the studied factor. Susceptibility to imipenem (a carbapenem) increased by 13–16%. Susceptibility to aminoglycosides and fluoroquinolones changed only occasionally and very slightly (within 3–9%) under the influence of the adaptogens. Further research is needed to clarify the potential risks …
creator: Irina Stanislavovna Shulga
creator: Marina Evgenievna Ostyakova
rights: Copyright (c) 2026 Shulga I.S., Ostyakova M.E. https://creativecommons.org/licenses/by-nc/4.0
license: https://creativecommons.org/licenses/by-nc/4.0
date: 2026-02-25
publication date: 2026-02-25
volume: 20
number: 4
starting page: 670
ending page: 680
doi: 10.22363/2312-797X-2025-20-4-670-680