Relationship between immunogenic and antigenic activity of the vaccine against colibacteriosis of animals

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Abstract

Studies of such quality indicators as immunogenic and antigenic activity of the vaccine against colibacteriosis of animals have been carried out in experiments with laboratory animals. Immunogenic activity was determined by vaccination of white mice with different doses of the vaccine, followed by infection with virulent strains of Escherichia , producers of adhesive antigens, and determination of ID The antigenic activity of the vaccine was studied in experiment on rabbits by determining the level of antibodies to adhesive antigens in agglutination reaction in blood serum of vaccinated animals. The relationship between immunogenic and antigenic activity of the vaccine was detected by studying preventive activity of sera obtained from vaccinated rabbits in the experiment on white mice. The analysis of the obtained research results was given. The relationship between the level of antibodies to adhesive antigens in the blood serum of vaccinated animals and the immunogenic activity of the vaccine in the experiment on laboratory animals was established.

About the authors

Alsu A. Galiakbarova

Peoples Friendship University of Russia (RUDN University); The Russian state center for animal feed and drug standardization and quality

Author for correspondence.
Email: Alsu.anvarovna.st@mail.ru

PhD student, Institute of Biochemical Technology and Nanotechnology; Researcher, Laboratory for Quality and Standardization of Bacterial Medicines, The Russian state center for animal feed and drug standardization and quality

Moscow, Russian Federation

Mikhail K. Pirozhkov

The Russian state center for animal feed and drug standardization and quality

Email: misha.pirojkov@yandex.ru

Doctor of Veterinary Sciences, Leading Researcher, Laboratory for Quality and Standardization of Bacterial Medicines

Moscow, Russian Federation

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Copyright (c) 2020 Galiakbarova A.A., Pirozhkov M.K.

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