The effectiveness of the use of Aminoseleferon-B with immunodeficiency in highly productive cows under conditions of technogenic environmental load

Cover Page

Cite item

Full Text

Abstract

Highly productive animals, which are characterized by a more intense metabolism and regulation of the neurohumoral system, are more sensitive to a pool of adverse environmental conditions and can often be accompanied by metabolic disorders, a decrease in the immunobiological status of the macroorganism, reproductive function disorders and the development of pathological processes of various etiology and localization. The studies were carried out in the conditions of a large dairy complex in the Voronezh region located 25 km from a chemical plant for the production of mineral fertilizers: ammonia, ammonium nitrate, nitric acid. Its total emissions to the environment are 5316.5 tons per year, including 4480.3 tons of gases. Studies have been carried out to study the effectiveness of the use of Аminoseleferon-B to correct the immune status of highly productive cows in an immunodeficient state, under conditions of technogenic environmental stress. It was established that Аminoseleferon-B contributed to the activation of humoral and cellular links of nonspecific immunity, the reduction of birth and postpartum pathology, the increase in the effectiveness of treatment, and the improvement of reproductive function.

Full Text

Table 1 Immunological indicators of cows

Indicators

Аnimal groups

First

Second

Third

Before drug administration

General immunoglobulins, g/l

32.28±1.58

31.65±1.43

31.47±1.29

BABS,%

76.23±1.36

76.41±1.09

75.84±1.20

LABS, mkg/ml

1.62±0.065

1.67±0.093

1.60±0.048

CIC, g/l

0.858±0.042

0.792±0.053

0.864±0.034

T-lymphocytes,%

30.26±1.17

30.69±1.19

30.12±0.96

B-lymphocytes,%

14.72±0.20

14.43±0.21

14.34±0.20

PAL,%

73.36±1.56

73.51±1.95

72.84±1.17

PI, units

3.62±0.21

3.58±0.18

3.42±0.16

PN, units

2.68±0.10

2.52±0.14

2.47±0.13

After drug administration

General immunoglobulins, g/l

30.73±1.17

35.28±1.31º

36.72±1.11*ºº

BABS,%

77.16±1.23

82.33±1.18**º

84.72±1.25***ºº

LABS, mkg/ml

1.68±0.053

1.88±0.042º

1.97±0.051***ººº

CIC, g/l

0.869±0.086

0.540±0.079 *º

0.521±0.065**º

T-lymphocytes,%

29.43±0.96

34.62±1.12*ºº

37.25±1.14***ººº

B-lymphocytes,%

14.20±0.42

16.25±0.44**ºº

17.46±0.34***ººº

PAL,%

72.09±1.93

79.64±1.48*º

82.18±1.14***ºº

PI, units

3.47±0.27

4.18±0.27

4.21±0.22*

PN, units

2.63±0.09

2.95±0.16

3.26±0.12**ºº

Note: * – p < 0.05; ** – p < 0.01; *** – р < 0.001 – to the initial data; º – р < 0.05; ºº – р < 0.01; ººº – р < 0.001 – to the first group.

 

Table 2. The degree of manifestation of birth and postpartum diseases

Indicators

Groups of cows

First

Second

Third

Pathology of childbirth, heads /%:

including difficult births, heads/% retention of placenta, heads /%

3/30.0

2/20.0

1/10.0

2/20.0

1/10.0

1/10.0

2/20.0

2/20.0

0/0

Pathology of the postpartum period, heads /% subinvolution of the uterus, heads /%

endometritis, heads /%

7/70.0

2/20.0

5/50.0

5/50.0

2/20.0

3/30.0

3/30.0

1/10.0

2/20.0

 

Table 3. Indicators of the effectiveness of the treatment of cows with postpartum pathology

Indicators

Groups of cows

First

Second

Third

Treated cows, heads

7

5

3

Recovered, heads

7

5

3

Therapeutic effect,%

100

100

100

Number of drug injections

6.8±0.42

5.2±0.37*

4.8±0.31**

Duration of treatment, days

9.5±0.71

7.4±0.46*

6.7±0.52*

Note: * – p<0.05; ** – p<0.01 – to the initial data.

 

Table 4. Indicators of reproductive function in cows

Indicators

Groups of cows

First

Second

Third

Period from calving to fertilization, days

114.3±10.2

99.2±11.4

96.5±10,4

Fertility at the first insemination,%

50.0

60.0

60.0

Insemination index, units

2.8±0.24

2.5±0.20

2.3±0.22

×

About the authors

Ivan T. Shaposhnikov

Russian Research Veterinary Institute of Pathology, Pharmacology and Therapy

Email: 36011958@mail.ru
ORCID iD: 0000-0003-0190-9083

Doctor of Biological Sciences, Head of the Laboratory of Toxicology, Risk Assessment of the Safety of Raw Materials and Products of Biological Origin

114 b Lomonosov st., Voronezh, 394087, Russian Federation

Vladimir N. Kotsarev

Russian Research Veterinary Institute of Pathology, Pharmacology and Therapy

Email: ldmvdc@mail.ru
ORCID iD: 0000-0002-9114-7176

Doctor of Veterinary Sciences, Leading Researcher

114 b Lomonosov st., Voronezh, 394087, Russian Federation

Vladimir N. Skorikov

Russian Research Veterinary Institute of Pathology, Pharmacology and Therapy

Author for correspondence.
Email: skorikov75@yandex.ru
ORCID iD: 0000-0002-3135-5811

Candidate of Veterinary Sciences, Senior Researcher

114 b Lomonosov st., Voronezh, 394087, Russian Federation

References

  1. Lifshits S, Glyaznetsova Y, Erofeevskaya L, Chalaya O, Zueva I. Effect of oil pollution on the ecological condition of soils and bottom sediments of the arctic region (Yakutia). Environ Pollut. 2021;288:117680. doi: 10.1016/j.envpol.2021.117680
  2. Kalugina OV, Shergina OV, Mikhailova TA. Ecological condition of natural forests located within the territory of a large industrial center, Eastern Siberia, Russia. Environ Sci Pollut Res. 2020;27(18):22400-22413. doi: 10.1007/s11356-020-08718-z
  3. Vatnikov Y, Donnik I, Kulikov E, Karamyan A, Notina E, Bykova I, Bannoud G, Bondareva I, Shlindova E, Sotnikova E, Lenchenko E, Rudenko A, Rudenko V, Rudenko P. Effectiveness of Hypericum perforatum L. phytosorbent as a part of complex therapy for acute non-specific bronchopneumonia. International Journal of Pharmaceutical Research. 2020;12(S.1):1108-1116. doi: 10.31838/ijpr/2020.SP1.165
  4. Frie MC, Sporer KR, Wallace JC, Maes RK, Sordillo LM, Bartlett PC, Coussens PM. Reduced humoral immunity and atypical cell-mediated immunity in response to vaccination in cows naturally infected with bovine leukemia virus. Vet Immunol Immunopathol. 2016;182:125-135. doi: 10.1016/j.vetimm.2016.10.013
  5. Shaposhnikov IT, Kotsarev VN, Brigadirov YN, Statsenko EI, Lobanov AE. Hematological and immunobiochemical status of highly productive cows in the area of industrial emissions into the atmosphere. Bulletin of veterinary pharmacology. 2018;(1):87-93. (In Russ). doi: 10.17238/issn2541-8203.2018.1.87
  6. Rudenko P, Sachivkina N, Vatnikov Y, Shabunin S, Engashev S, Kontsevaya S, Karamyan A, Bokov D, Kuznetsova O, Vasilieva E. Role of microorganisms isolated from cows with mastitis in Moscow region in biofilm formation. Veterinary World. 2021;14(1):40-48. doi: 10.14202/vetworld.2021.40-48
  7. Albernaz TT, Leite RC, Reis JK, de Sousa Rodrigues AP, da Cunha Kassar T, Resende CF, de Oliveira CH, Silva Rd, Salvarani FM, Barbosa JD. Molecular detection of bovine immunodeficiency virus in water buffaloes (Bubalus bubalis) from the Amazon region, Brazil. Trop Anim Health Prod. 2015;47(8):1625-1628. doi: 10.1007/s11250-015-0884-6
  8. Vatnikov Y, Shabunin S, Kulikov E, Karamyan A, Murylev V, Elizarov P, Kuznetsova O, Vasilieva E, Petukhov N, Shopinskaya M, Rudenko A, Rudenko P. The efficiency of therapy the piglets gastroenteritis with combination of Enrofloxacin and phytosorbent Hypericum perforatum L. International Journal of Pharmaceutical Research. 2020;12(S.2):3064-3073. doi: 10.31838/ijpr/2020.SP2.373
  9. Zamotaiev OM, Postupalenko VY, Shvadchak VV, Pivovarenko VG, Klymchenko AS, Mély Y. Improved hydration-sensitive dual-fluorescence labels for monitoring peptide-nucleic acid interactions. Bioconjug Chem. 2011;22(1):101-107. doi: 10.1021/bc100434d
  10. Palikov VA, Palikova YA, Borozdina NA, Nesmeyanova EN, Rudenko PA, Kazakov VA, Kalabina EA, Bukatin MV, Zharmukhamedova TYu, Khokhlova ON, Dyachenko IA. A novel view of the problem of Osteoarthritis in experimental rat model. Research Results in Pharmacology. 2020; 6(2):19-25. doi: 10.3897/rrpharmacology.6.51772
  11. Rajawat YS, Humbert O, Kiem HP. In-vivo gene therapy with foamy virus vectors. Viruses. 2019; 11(12):1091. doi: 10.3390/v11121091
  12. Shaposhnikov IT, Kotsarev VN, Mikhailov EV, Chusova GG. Some indicators of the clinical state of highly productive cows with different functional activity of the liver, which are in conditions of ecological trouble. Bulletin of veterinary pharmacology. 2020;1(10):86-95. (In Russ). doi: 10.17238/issn2541-8203.2020.1.86
  13. Vatnikov Y, Yousefi M, Engashev S, Rudenko P, Lutsay V, Kulikov E, Karamyan A, Dremova T, Tadzhieva A, Strizhakov A, Kuznetsov V, Yagnikov S. Clinical and hematological parameters for selecting the optimal dose of the phytopreparation «Deprim», containing an extract of the herb Hypericum perforatum L., in husbandry. International Journal of Pharmaceutical Research. 2020; 12(S.1):2731-2742. doi: 10.31838/ijpr/2020.SP1.401
  14. Wisnieski L, Norby B, Gandy J, Byrem TM, Sordillo LM. Changes in bovine leukemia virus serological status and lymphocyte count between dry-off and early lactation in Michigan dairy cows. J Dairy Sci. 2020; 103(10):9473-9480. doi: 10.3168/jds.2019-17839
  15. Marawan MA, Alouffi A, El Tokhy S, Badawy S, Shirani I, Dawood A, Guo A, Almutairi MM, Alshammari FA, Selim A. Bovine Leukaemia Virus: current epidemiological circumstance and future prospective. Viruses. 2021;13(11):2167. doi: 10.3390/v13112167
  16. Vatnikov Y, Donnik I, Kulikov E, Karamyan A, Sachivkina N, Rudenko P, Tumanyan A, Khairova N, Romanova E, Gurina R, Sotnikova E, Bondareva I. Research on the antibacterial and antimycotic effect of the phytopreparation Farnesol on biofilm-forming microorganisms in veterinary medicine. International Journal of Pharmaceutical Research. 2020;12(S.2):1481-1492. doi: 10.31838/ijpr/2020.SP2.164
  17. Erskine RJ, Bartlett PC, Byrem TM, Render CL, Febvay C, Houseman JT. Association between bovine leukemia virus, production, and population age in Michigan dairy herds. J Dairy Sci. 2012;95(2):727-734. doi: 10.3168/jds.2011-4760

Copyright (c) 2022 Shaposhnikov I.T., Kotsarev V.N., Skorikov V.N.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies