Structural changes in rats organism in experimental intoxication with herbicide 2,4-DA

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In subacute toxicity herbicide 2,4-DA LD50, in the macroscopic examination of organs in rats set changes inherent poisoning by toxic substances. Heart muscle and kidneys flabby, uneven coloring. Lung red-pink color with areas of acute atelectasis. By light and electron microscopy, we found that the herbicide 2,4-DA has polytropic effect on experimental animals. In the myocardium revealed foci of necrosis where cardiomyocytes have fuzzy outlines and poor color. Structural changes are accompanied by an increase in the number of infiltration of lymphocytes and macrophages. In the kidneys due to necrotic and degenerative changes in the tubules of nephrons organ's parenchyma becomes grayish color. In the walls of medium and small bronchi of lung localized massive lymphocytic infiltration. The interalveolar septum tissue greatly expanded due to the large number of white blood cells. In all investigated organs disorders found blood and lymph circulation.

About the authors

S M Shakirova

Bashkir State Agrarian University

Author for correspondence.
50 years of October str., 34, Ufa, Russia, 450001

G R Shakirova

Moscow State Academy of Veterinary Medicine and Biotechnology named after K.I. Skryabin

Scriabin str., 23, Moscow, Russia, 109472


Copyright (c) 2016 Шакирова С.М., Шакирова Г.Р.

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