Feline squamous cell carcinoma: morphologic predictors of survival and an experimental prognostic model

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Abstract

Understanding the causes and mechanisms of squamous cell carcinoma in animals is an important issue in veterinary medicine and basic science. This study provides a detailed analysis of the interaction between oncogenic processes and develops a preliminary algorithm and mathematical model for predicting survival based on tumor morphology, with an emphasis on cases showing atypical cellular structures. There is no clear consensus on the etiology of malignant cell transformation in cats, nor are there well-defined criteria for differentiating contributing factors in squamous cell carcinoma (SCC). Predicting survival and metastasis of SCC in cats remains challenging despite advances such as standardized systems. The study revealed a relationship between morphological characteristics of SCC in cats and survival: degree of differentiation, cellular atypism, bone invasion, mitotic index, and necrosis. An experimental model has been developed to predict risks but requires validation on independent datasets due to the small sample size. Recommendations for implementing the model in veterinary practice have been developed. Thus, further investigation of factors influencing feline cancer development is essential. This will aid not only in predicting survival but also in the effective prevention and treatment of cancer - a key goal of modern oncology.

About the authors

Nare A. Akopyan

MSUTU named after K.G. Razumovsky (PKU)

Author for correspondence.
Email: parlenare@gmail.com
ORCID iD: 0000-0002-3897-6784
SPIN-code: 2597-3654

Candidate of Biological Sciences (PhD), Associate Professor Department of Biology and Bioinformatics

73 Zemlyanoy Val St., Moscow, 109004, Russian Federation

Valery N. Baimatov

Moscow State Academy of Veterinary Medicine and Biotechnology named after K.I. Scriabin MBA

Email: baimatov.valeri@yandex.ru
ORCID iD: 0000-0001-6732-4729
SPIN-code: 9905-7190

Professor, Doctor of Veterinary Sciences Department of General Pathology named after V.M. Koropov

23, Academician Skryabin St., Moscow, 109472, Russian Federation

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